摘要
目的通过对5245例确诊的食管癌患者进行随访,了解其生存现状及影响因素,为食管癌的预后评价及防治提供参考。方法收集新疆医科大学附属肿瘤医院信息系统中2010年1月1日-2019年12月31日确诊的5245例食管癌患者的临床病历资料。采用门诊、电话方式随访出院患者,了解患者生存情况,以食管癌患者全死因死亡为终点事件,随访时间为2010年1月1日-2021年1月14日。采用寿命表法计算生存率,对影响预后的单因素分析采用Log-rank检验,对影响预后的多因素分析采用Cox比例风险回归模型进行分析。结果5245例食管癌患者中,全死因死亡3150例,生存1418例,失访677例,病死率为60.05%。1年、3年、5年生存率分别为42.0%、29.0%、25.0%,中位生存期为16个月。预后因素分析结果显示,患者性别、发病年龄、肿瘤分期、病理诊断、T分期、N分期、M分期为食管癌患者长期生存状况的影响因素。结论男性、年龄>75岁、肿瘤分期Ⅲ期及以上、未分化癌、存在淋巴结转移及存在远处肿瘤转移的食管癌患者死亡风险更高,应推进食管癌早筛早诊早治工作,保障食管癌患者生存期和生命质量,减轻食管癌的疾病负担。
Objective Through the follow-up of 5245 patients with esophageal cancer,to understand their survival status and influencing factors,so as to provide the reference for prognosis evaluation,prevention and treatment of esophageal cancer.Methods The clinical records of 5245 patients with esophageal cancer diagnosed from January 1,2010 to December 31,2019 of information system in the hospital were collected.Outpatient and telephone follow-up of discharged patients were used to understand patient survival,with all-cause death of esophageal cancer patients as endpoint event,and the follow-up period was from January 1,2010 to January 14,2021.The life table method was used to calculate the survival rate;the log-rank test was used for analysis of single factors affecting prognosis,and the proportional risk regression model was used for analysis of multiple factors affecting prognosis.Results Among 5245 patients with esophageal cancer,3150 died from all causes of death,1418 survived,677 lost to follow-up,and the fatality rate was 60.05%.The 1-year,3-year and 5-year survival rates were 42.0%,29.0%and 25.0%.The median survival was 16 months.The results of prognostic factor analysis showed that patient gender,age of onset,tumor stage,pathological diagnosis,and TNM stage were the influencing factors of long-term survival status in esophageal cancer patients.Conclusion Male,age>75 years old,stage of tumor greater than 3 period,undifferentiated carcinoma,regional lymph nodes metastasis and distant metastasis of esophageal cancer patients had a higher risk of death.Early screening,early diagnosis and early treatment of esophageal cancer should be promoted to ensure survival time and quality of life in patients with esophageal cancer,and to reduce disease burden of esophageal cancer.
作者
刘新亚
夏文俊
赵婷
周听松
曹明芹
LIU Xinya;XIA Wenjun;ZHAO Ting;ZHOU Tingsong;CAO Mingqin(The Affiliated Tumor Hospital,Urumqi 830011,China;School of Public Health,Xinjiang Medical University,Urumqi 830017,China)
出处
《新疆医科大学学报》
CAS
2022年第6期685-690,共6页
Journal of Xinjiang Medical University
基金
国家自然科学基金(71663053)。
关键词
食管癌
生存分析
生存率
影响因素
esophageal cancer
survival analysis
survival rate
influencing factors
