摘要
目的:探究对开角型青光眼患者使用胞磷胆碱钠片联合马来酸噻吗洛尔滴眼液进行治疗的效果与安全性。方法:选取2018年2月至2020年2月绵阳市中心医院接诊的80例开角型青光眼患者进行分组研究。随机将其分为观察组(n=40)和对照组(n=40)。为对照组患者采用胞磷胆碱钠片进行治疗,为观察组患者采用胞磷胆碱钠片联合马来酸噻吗洛尔滴眼液进行治疗。然后比较两组患者的治疗效果。结果:观察组患者治疗的总有效率高于对照组患者,差异有统计学意义(P<0.05)。治疗后,观察组患者的眼压、眼部视网膜中央动脉(CRA)的血流阻力指数(RI)均低于对照组患者,其CRA的收缩期峰值血流速度(PSV)、舒张末期血流速度(EDV)均高于对照组患者,差异有统计学意义(P<0.05)。治疗后,两组患者不良反应的发生率相比,差异无统计学意义(P>0.05)。结论:对开角型青光眼患者采用胞磷胆碱钠片联合马来酸噻吗洛尔滴眼液进行治疗的临床效果确切,能够改善患者的眼部供血,减轻其眼部的损伤,且安全性较高。
Objective:To explore the efficacy and safety of cyticoline sodium tablets combined with timolol maleate eye drops in the treatment of patients with open-angle glaucoma.Methods:A total of 80 patients with open-angle glaucoma treated in Mianyang Central Hospital from February 2018 to February 2020 were selected and divided into groups.They were randomly divided into observation group(n=40)and control group(n=40).Patients in the control group were treated with citicoline sodium tablets,and patients in the observation group were treated with citicoline sodium tablets combined with timolol maleate eye drops.Then the treatment effects of the two groups were compared.Results:The total effective rate of observation group was higher than control group,the difference was statistically significant(P<0.05).After treatment,iOP and RI of central retinal artery(CRA)in observation group were lower than those in control group,and peak systolic flow velocity(PSV)and end diastolic flow velocity(EDV)of CRA in observation group were higher than those in control group,the differences were statistically significant(P<0.05).After treatment,there was no significant difference in the incidence of adverse reactions between 2 groups(P>0.05).Conclusion:Cyticoline sodium tablet combined with timolol maleate eye drops has a definite clinical effect on patients with openangle glaucoma,which can improve the blood supply to the eyes and reduce the damage to the eyes,with high safety.
作者
徐桃
XU Tao(Mianyang Central Hospital,Mianyang 621099,Sichuan,China)
