摘要
基于药智数据库、方剂现代应用数据库,探讨古今方剂治疗鼻窦炎的用药规律。搜集药智数据库、方剂现代应用数据库中主治疾病为鼻窦炎、鼻渊、脑漏、脑渊的中药方剂,运用频次分析、关联规则分析和因子分析等方法,探究鼻窦炎治疗方剂的组方规律。共纳入87首研究方剂,涉及5种鼻窦炎证型和160味中药;这些中药多为解表药、清热药、补虚药;且以性寒、温,味辛、苦入肺经或性温,味辛入脾经为主。拓扑学筛选得到白芷、辛夷、甘草、苍耳子、黄芩等17味核心中药。辛夷、白芷、苍耳子等中药在肺经风热型鼻窦炎治疗中更为常用;甘草、辛夷、白芷、川芎等中药则是脾胃湿热型鼻窦炎治疗的关键配伍。2种证型的数据因子分析均提取到6个公因子。临床治疗鼻窦炎宜选用性寒、温,味辛的解表药、清热药、补虚药,注重辨证论治,把握关键治法。
Based on the Drugdataexpy and the prescription modern application database,this study explored the formulation regularity of ancient and modern prescriptions for the treatment of sinusitis.The Chinese medicinal prescriptions for the treatment of sinusitis with various syndromes were retrieved from the above databases and the corresponding formulation regularity was investigated by frequency analysis,association rule analysis,and factor analysis.Eighty-seven Chinese medicinal prescriptions were included,involving five syndrome types of sinusitis and 160 Chinese medicine,which were mainly effective in releasing exterior,clearing heat,and tonifying deficiency,and acted on the lung meridian due to cold and warm nature and pungent and bitter flavor or on the spleen meridian due to warm nature and pungent flavor.Seventeen core Chinese medicine were screened out by topological data analysis,including Angelicae Dahuricae Radix,Magnoliae Flos,Glycyrrhizae Radix et Rhizoma,Xanthii Fructus,and Scutellariae Radix.Chinese medicine such as Magnoliae Flos,Angelicae Dahuricae Radix,and Xanthii Fructus were commonly used in the treatment of sinusitis of wind-heat in the lung meridian,while the combination of Glycyrrhizae Radix et Rhizoma,Magnoliae Flos,Angelicae Dahuricae Radix,Chuanxiong Rhizoma,etc.was the key compatibility in treating sinusitis of dampness-heat in the spleen and stomach.Six common factors were extracted from the factor analysis of the above two syndrome types.The findings indicate that the exterior-releasing,heat-clearing,and deficiency-tonifying Chinese medicine with cold and warm nature and pungent flavor are preferential options for the clinical treatment of sinusitis.Treatment should be based on syndrome differentiation and key therapeutic principles should be followed.
作者
王博龙
吴春兴
易增兴
胡永生
WANG Bo-long;WU Chun-xing;YI Zeng-xing;HU Yong-sheng(Yichun University,Yichun 336000,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2022年第4期1114-1119,共6页
China Journal of Chinese Materia Medica
基金
江西省教育厅科技项目(GJJ12596)。
关键词
鼻窦炎
证型
数据挖掘
核心中药
用药规律
sinusitis
syndrome type
data mining
core Chinese medicine
formulation regularity
