摘要
目的 观察地夸磷索钠眼液治疗中重度干眼的临床疗效。方法 随机对照临床试验研究,对符合条件的中重度干眼患者180例,采用随机数字表法分为研究组和对照组。研究组给与地夸磷索钠眼液联合人工泪液治疗,对照组给与双氯芬酸钠眼液联合人工泪液治疗。分别于治疗前和治疗4周后对患者的干眼症状进行评分,并记录泪膜破裂时间(BUT)、基础泪液分泌试验(SIt)和角膜荧光素染色评分。结果 完成随访156例,研究组和对照组治疗前和治疗4周后的干眼症状评分、BUT、SIt和角膜荧光素染色评分均存在显著差异(P<0.001)。治疗4周后,研究组和对照组干眼症状评分、BUT、SIt、角膜荧光素染色评分的差异均显著(P<0.05)。结论 研究组和对照组均能能显著改善中重度干眼患者的症状和体征,并且研究组的疗效更好。
Objective To evaluate the efficacy of diquafosol tetrasodium eye drops in moderate to severe dry eye patients. Methods In this prospective clinical study, a total of 180 patients(180 eyes) were randomly divided into two groups : experimental group and control group based on the criteria. In the control group, patients were treated with artificial tear drops for 6 s/d and diclofence sodium eye drops 4 s/d;In experimental group, patients were treated with diquafosol tetrasodium for 6 s/d and artificial tear for 6 s/d. Scores of ocular surface disease index(OSDI), break-up time(BUT), SchirmerⅠtest(SⅠt), corneal fluorescein staining were observed 4 weeks after treatment. Results 156 patients were included for statistical analyses after the exclusion of 14 patients who were lost for follow. After 4 weeks of treatment, the scores of OSDI, BUT, SⅠt and corneal fluorescein staining for the patients in the experimental group and in the control group both had improved significantly(P<0.001);the effect in the experimental group was better than that in the control group for the scores of OSDI, BUT, SⅠt and corneal fluorescein staining(P<0.05). Conclusions Both two groups of patients had effectively improve the clinical symptoms and signs of moderate to severe dry eyes, and the effect in the experimental group was better than that in the control group.
作者
刘明杰
王芳
郝晨红
LIU Mingjie;WANG Fang;HAO Chenhong(Department of Ophthalmology,Dalian Friendship Hospital,Dalian 116001,China)
出处
《航空航天医学杂志》
2022年第4期406-408,共3页
Journal of Aerospace medicine
关键词
干眼
P2Y2受体
泪膜
随机对照试验
临床疗效
dry eye
P2Y2 receptor
tear film
Randomized controlled trials
clinical efficacy
