摘要
目的:探讨氨磺必利与利培酮对首发精神分裂症患者临床症状和糖脂代谢的影响。方法:遴选82例首发精神分裂症患者随机分为利培酮组(n=41)和氨磺必利组(n=41),利培酮组给予利培酮治疗,氨磺必利组给予氨磺必利治疗,观察两组治疗前后精神症状、临床疗效、治疗前后血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、泌乳素(PRL)水平及治疗前后糖脂代谢指标变化。结果:治疗后,氨磺必利组患者阳性与阴性症状量表(PANSS)中阴性症状、一般病理症状及PANSS总分明显低于利培酮组;组间临床总有效率对比,氨磺必利组显著高于(95.12%)利培酮组(80.49%);治疗后,氨磺必利组血清IL-6、TNF-α、PRL改善情况明显优于利培酮组;对比空腹血糖(FBG)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平发现,治疗后,氨磺必利组组内差异无统计学意义,利培酮组组内及两组间差异均有统计学意义。结论:氨磺必利可有效改善精神分裂症患者精神症状,尤其针对阴性症状改善效果优于利培酮,对PRL及糖脂代谢水平影响小于利培酮,临床应用安全、有效。
Objective To explore the effects of amisulpride and risperidone on clinical symptoms and glucose and lipid metabolism in patients with first-episode schizophrenia.Methods 82 cases of patients with first-episode schizophrenia were randomly divided into risperidone group (n=41) and amisulpride group (n=41).Risperidone group was given risperidone,and amisulpride group was given amisulfatide.The psychiatric symptoms,clinical efficacy,levels of serum interleukin-6(IL-6),tumor necrosis factor-α (TNF-α) and prolactin (PRL),and indexes of glucose and lipid metabolism before and after treatment were observed in the two groups.Results After treatment,the scores of positive symptoms and general pathological symptoms in the positive and negative symptom scale (PANSS),and the total PANSS score of amisulpride group were significantly lower than those of risperidone group.The total clinical effective rate in amisulpride group was significantly higher than that in risperidone group (95.12% vs 80.49%).After treatment,the improvement of serum IL-6,TNF-α and PRL levels in amisulpride was significantly better than that in risperidone group.There was no statistically significant difference in levels of fasting blood glucose (FBG),total cholesterol (TC),triglyceride (TG),high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) within amisulpride group after treatment,and there were statistically significant differences in the above levels within risperidone group and between the two groups.Conclusions Amisulpride can effectively improve the psychiatric symptoms of patients with schizophrenia,especially its improvement of negative symptoms is better than risperidone,and it has smaller effects on levels of PRL and glucose and lipid metabolism than risperidone,therefore it has safe and effective clinical application.
作者
熊智磊
孙娟
童庆好
Xiong Zhi-lei;Sun Juan;Tong Qing-hao(Department of Psychiatry,Second People's Hospital of La'an City,Affiliated Hospital of Wanxi Vocational Health College,Lu'an 237005,China)
出处
《湖南师范大学学报（医学版）》
2022年第1期91-94,共4页
Journal of Hunan Normal University(Medical Sciences)
关键词
首发精神分裂症
氨磺必利
利培酮
糖脂代谢
first-episode schizophrenia
amisulpride
risperidone
glucose and lipid metabolism
