摘要
目的检测并分析慢性阻塞性肺疾病急性加重期(AECOPD)患者4种常见病原体的感染情况。方法抽取平湖市第一人民医院2019年10月-2021年9月住院治疗的AECOPD患者330例为研究对象,采用聚合酶链式反应(PCR)技术检测巨细胞病毒(CMV)、呼吸道合胞病毒(RSV)、EB病毒(EBV),肺炎支原体(MP),并对感染情况进行分析。结果共检出阳性患者82例,总阳性率为24.8%(82/330),其中混合感染11例。CMV检出率最高(10.6%),其次是RSV(7.3%)EBV(6.4%)MP(3.9%)。不同年龄段及性别病原体阳性率差异均无统计学意义(P>0.05);病毒阳性组和阴性组白细胞计数、C-反应蛋白、降钙素原等感染指标差异均无统计学意义(P>0.05);各病原体流行季节明显不同,其中RSV和MP以春冬季好发,而CMV8月、9月感染率最高,EVB5月、6月感染率最高。结论AECOPD与呼吸道病原体感染密切相关,在好发季节应做好预防工作。
Objective The infection status of four common pathogens in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)was detected and analyzed.Methods AECOPD patients hospitalized in the respiratory department of our hospital from October 2019 to September 2021 were selected for the detection of Cytomegalovirus(CMV),respiratory syncytial virus(RSV),EB virus(EBV)and Mycoplasma pneumoniae(MP)with polymerase chain reaction(PCR),and the results were analyzed.Results A total of 82 positive patients(24.8%,82/330)were detected,including 11 cases of mixed infection.The detection rate of CMV was the highest(10.6%),followed by RSV(7.3%),EBV(6.4%)and MP(3.9%).There was no statistical significance on the difference in pathogen positive rate among different age groups and genders(P>0.05).There was no statistical significance on the differences in WBC count,C-reactive protein,procalcitonin and other infection indexes between virus-positive and virus-negative groups(P>0.05).RSV and MP were most prevalent in spring and winter,while CMV infection rate was the highest in August and September,and EVB infection rate was the highest in May and June.Conclusion AECOPD is closely related to respiratory pathogen infection,preventive work should be done well in epidemic seasons.
作者
胡晓飞
许世佳
薛河东
HU Xiao-fei;XU Shi-jia;XUE He-dong(Department of Clinical Laboratory,the First People’s Hospital of Pinghu,Pinghu,Zhejiang 314200,China;不详)
出处
《中国卫生检验杂志》
CAS
2022年第11期1343-1345,1349,共4页
Chinese Journal of Health Laboratory Technology
基金
浙江省平湖市科技计划项目(2018-42)。
关键词
慢性阻塞性肺疾病
急性加重期
巨细胞病毒
呼吸道合胞病毒
EB病毒
肺炎支原体
Pulmonary disease
Chronic obstructive
Acute exacerbation
Cytomegalovirus
Respiratory syncytial virus
EB virus
Mycoplasma pneumoniae
