摘要
目的 评价维生素C联合舒芬太尼应用于腹腔镜全子宫切除术后的镇痛效果。方法 选取择期行腹腔镜全子宫切除术患者120例,随机分为对照组(S组)、维生素C 3 g组(SC1组)、维生素C 6 g组(SC2组),每组40例。所有患者采取统一的麻醉方案,术后均采用患者自控静脉镇痛(PCIA),S组镇痛液配方为舒芬太尼3.0μg·kg^(-1)+托烷司琼5 mg+氯化钠注射液至200 mL,SC1组、SC2组在此基础上加用维生素C 3、6 g。ELISA法检测麻醉诱导前、术后8、12、24 h血清5羟色胺(5-HT)、去甲肾上腺素(NE)含量,观察术后镇痛效果和不良反应发生情况。结果 术后2、8、12、24 h,与S组相比,SC1组和SC2组的疼痛视觉模拟量表(VAS)评分均降低(P <0.05),且术后8、12 h SC2组VAS评分低于SC1组(P <0.05)。术后8、12、24 h,与S组相比,SC1组和SC2组血清5-HT、NE含量均降低(P <0.05),且术后8、12 h SC2组血清5-HT、NE含量低于SC1组。与S组相比,SC1组和SC2组术后镇痛泵有效按压次数下降(P <0.05),3组术后补救镇痛药例数及恶心呕吐发生率比较无显著差异(P> 0.05)。结论 维生素C联合舒芬太尼PCIA用于腹腔镜全子宫术后镇痛效果确切,且可减少舒芬太尼用量。
AIM To evaluate the analgesic effect of vitamin C combined with sufentanil after laparoscopic total hysterectomy. METHODS One hundred and twenty patients undergoing elective laparoscopic total hysterectomy were randomly divided into control group(group S), vitamin C 3 g group(group SC1) and vitamin C 6 g group(group SC2),with 40 cases in each group. All patients received a unified anesthesia plan, and patient controlled intravenous analgesia(PCIA) was used after surgery. The group S received sufentanil 3.0 μg·kg^(-1) + tropisetron 5 mg + sodium chloride injection to 200 mL, the group SC1 and group SC2 received vitamin C 3 and 6 g on the basis of the group S. The contents of serum serotonin(5-HT) and norepinephrine(NE) were measured by ELISA before anesthesia induction and 8, 12, 24 h after operation. The analgesic effect and adverse reactions after operation were observed. RESULTS The visual analogue scale(VAS) scores of pain in the group SC1 and group SC2 were lower than those in the group S at 2, 8, 12 and 24 h after operation(P < 0.05), and the VAS score at 8 and 12 h after operation in the group SC2 was lower than that in the group SC1(P < 0.05).The contents of serum 5-HT and NE in the group SC1 and group SC2 were lower than those in the group S at 8, 12 and 24 h after operation(P < 0.05), and the contents of 5-HT and NE in the group SC2 were lower than those in the group SC1 at 8and 12 h after operation. Compared with the group S, the effective pressure times of postoperative analgesia pump decreased in the group SC1 and group SC2(P < 0.05), but there was no significant difference in the number of postoperative rescue analgesics and the incidence of nausea and vomiting among the three groups(P > 0.05). CONCLUSION Vitamin C combined with sufentanil PCIA is effective in analgesia after laparoscopic total uterine surgery, and can reduce the dosage of sufentanil.
作者
左慕妍
吕雷帅
张宇航
李艳
ZUO Mu-yan;LÜ Lei-shuai;ZHANG Yu-hang;LI Yan(Department of Anesthesiology,Affiliated Hospital of Chengde Medical College,Chengde HEBEI 067000,China;Department of Cardiology,Affiliated Hospital of Chengde Medical College,Chengde HEBEI 067000,China)
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2022年第4期220-223,共4页
Chinese Journal of New Drugs and Clinical Remedies
基金
河北省研究生创新项目(CXZZSS2021142)。
关键词
维生素C
舒芬太尼
镇痛
妇科外科手术
vitamin C
sufentanil
analgesia
gynecologic surgical procedures
