摘要
吡喃酮类衍生物是一类具有生物活性的六元杂环化合物,同时,许多吡喃酮类化合物还是重要的有机合成中间体,广泛应用到医药,农药的合成中。本论文以氢氧化钠为碱,2-二乙硫基亚甲基乙酰乙酰苯胺和丙二腈合成了一系列新型多取代2-吡喃酮-3-甲酸,通过核磁共振、质谱分析对所得化合物的结构进行表征,并对该反应合成机理进行了探讨。该合成方法条件温和、操作安全、收率高。
Pyranones and their derivatives are one of the impertant six-membered heterocyclic compounds with biological activity,and are used as promising intermediates in the synthesis of pharmacy and pesticides.A series of novel polysubstituted 2-pyranone-3-formic acid compounds were synthesized from 2-bis(ethylthio)methylene acetoacetanilide and malononitrile in the presence of sodium hydroxide.The composition and structure had been characterized by ^(1)H NMR,^(13)C NMR and HR-MS.Moreover,the mechanism for the reaction was proposed in this paper.The reported synthesis had the advantages of mild conditions,safe operation and higher yields.
作者
任传清
寇高翔
邵先钊
季晓晖
季建伟
张强
REN Chuan-qing;KOU Gao-xiang;SHAO Xian-zhao;JI Xiao-hui;JI Jian-wei;ZHANG Qiang(Shaanxi Key Laboratory of Catalysis,Shaanxi University of Technology,Hanzhong 723000,China;School of Chemical and Environmental Science,Shaanxi Univrsity of Technology,Hanzhong 723000,China)
出处
《化学研究与应用》
CAS
CSCD
北大核心
2022年第6期1411-1416,共6页
Chemical Research and Application
基金
陕西省科技厅自然科学基础研究计划项目(2020JM-602)资助
陕西省教育厅基金项目(19JS011)资助
陕西省教育厅重点项目(20JS015)资助。
