摘要
目的研究早期呼吸训练改善胃食管反流病(GERD)临床症状的价值。方法选取2017年2月~2020年2月中日友好医院收治的GERD患者118例,随机数表法分为观察组与对照组,各59例,对照组以质子泵抑制剂(PPI)雷贝拉唑钠治疗,观察组在对照组基础之上辅助呼吸训练,治疗期间比较两组患者不良反应发生情况,比较两组患者治疗后疗效,比较两组患者治疗前后24 h不同体位食管pH≤4的时长,比较两组患者治疗前后24 h酸反流总次数及不同体位食管酸清除时间。结果观察组患者总有效率94.92%显著高于对照组总有效率81.36%,复发率13.56%显著低于对照组30.51%,差异有统计学意义(P<0.05)。两组患者治疗后24 h立位食管pH≤4的时长百分比、卧位食管pH≤4的时长百分比及食管pH≤4的总时长百分比均显著低于本组治疗前,观察组显著低于对照组,差异有统计学意义(P<0.05)。两组患者治疗后24 h酸反流总次数、立位食管酸清除时间、卧位食管酸清除时间与食管酸清除总时间均显著少于各组治疗前,观察组显著少于对照组治疗后,差异有统计学意义(P<0.05)。观察组患者不良反应总发生率与对照组比较,差异无统计学意义(P>0.05)。结论在采用PPI治疗GERD的基础上辅助呼吸训练可有效提高疗效,降低复发率及PPI治疗GERD的不良反应,减少患者食管内酸暴露时间及次数,提升食管酸清除能力,值得临床应用。
Objective To study the value of early respiratory training in improving the clinical symptoms of GERD.Methods A total of 118 GERD patients were randomly divided into the observation group and the control group,with 59 patients in each group.The control group was treated with rabeprazole sodium,and the observation group was assisted with respiratory training on the basis of the control group.The incidence of adverse reactions was compared between the two groups during treatment.The efficacy of the two groups after treatment was compared.The percentage of standing position,decubitus position and total esophageal pH≤4 in 2 groups before and after treatment were compared.The total acid reflux times in 24 h,and standing position,decubitus position,total esophageal acid removal time before and after treatment was compared between the two groups,Results The total effective rate of94.92%in the observation group was significantly higher than that of 81.36%in the control group,and the recurrence rate of 13.56%was significantly lower than 30.51%in the control group,the difference was statistically significant(P<0.05).After treatment,the percentage of standing position,decubitus position and total esophageal pH≤4 in the two groups were significantly lower than that before treatment,the difference was statistically significant(P<0.05).The percentage of standing position,decubitus position and total esophageal pH≤4 in the observation group were significantly lower than those in the control group after treatment,the difference was statistically significant(P<0.05).The number of total acid reflux 24 h after treatment,the removal time of esophageal acid in vertical position,the removal time of esophageal acid in decubitus position and the removal time of total esophageal acid in the two groups were significantly less than before treatment,the difference was statistically significant(P<0.05).The number of total acid reflux,esophageal acid removal time in vertical position,esophageal acid removal time in decubitus position and total esophageal acid removal time in observation group were significantly less than those in control group after treatment,the difference was statistically significant(P<0.05).The total incidence of adverse reactions in observation group was compared with control group,the difference was not statistically significant(P>0.05).Conclusion On the basis of the treatment of GERD with PPI,assisted respiratory training can effectively improve the efficacy,reduce the recurrence rate and adverse reactions of GERD treatment with PPI,reduce the exposure time and times of esophageal acid in patients,and improve the scavenging ability of esophageal acid.
作者
吴晓敏
魏静
徐静
杜时雨
Wu Xiaomin;Wei Jing;Xu Jing(Department of Gastroenterology,China-Japan Friendship Hospital,Beijing 100029,China)
出处
《中华保健医学杂志》
2022年第3期211-214,共4页
Chinese Journal of Health Care and Medicine
基金
北京市自然科学基金资助项目(7202181)。
关键词
呼吸训练
胃食管反流病
质子泵抑制剂
Respiratory training
Gastroesophageal reflux disease
Proton pump inhibitor
