摘要
目的探讨超声造影在肝转移性神经内分泌肿瘤(NETLM)鉴别诊断及引导消融治疗中的应用价值。方法选取29例NETLM患者(NETLM组)和30例非NETLM患者(NNETLM组),两组均行超声造影检查,获得时间-强度曲线定量参数始增时间、达峰时间、减退时间、峰值强度,比较两组上述参数的差异。绘制受试者工作特征(ROC)曲线分析各定量参数单独及联合诊断NETLM的效能。对29例NETLM患者行超声造影引导下消融治疗,观察肿瘤灭活情况。结果NETLM组达峰时间、减退时间、峰值强度分别为(23.52±4.44)s、(44.55±9.41)s、(19.79±3.45)dB,均高于NNETLM组,差异均有统计学意义(均P<0.05);两组始增时间比较差异无统计学意义。ROC曲线分析显示,始增时间、达峰时间、减退时间、峰值强度诊断NETLM的曲线下面积分别为0.549、0.657、0.809、0.777,联合应用诊断的曲线下面积为0.945,与各参数单独诊断比较差异均有统计学意义(Z=2.172、3.728、2.172、2.469,均P<0.05)。29例NETLM患者均顺利完成超声造影引导下消融治疗,其中26例经1次消融肿瘤完全灭活,2例经2次消融完全灭活,1例于消融后接受化疗干预后灭活。结论超声造影对NETLM有较好的诊断价值;且其引导下治疗可提高一次性消融成功率。
Objective diagnosis and guided ablation treatment of liver metastatic neuroendocrine tumors(NETLM).MethodsA retrospective analysis of 30 patients with non-neuroendocrine metastatic liver cancer(NNETLM)and 29 patients with NETLM were admitted.Contrastenhanced ultrasound was performed in both groups.The quantitative parameters of time-intensity curve,such as time to increase,peak time,decrease time and peak intensity,were obtained.The differences of the above parameters between the two groups were compared.Receiver operating characteristic(ROC)curve was drawn to analyze the value of each quantitative parameter in diagnosing NNETLM individually and combined.Twenty-nine patients with NETLM were treated with contrast-enhanced ultrasound-guided ablation,the condition of tumor inactivation was observed.Results peak intensity of NETLM group were(23.52±4.44)s,(44.55±9.41)s,and(19.79±3.45)dB,respectively,which were higher than those of NNETLM group,and the differences were statistically significant(all P<0.05).There was no statistically significant difference in the time to increase between the two groups.ROC curve analysis showed that the area under the curve of time to increase,peak time,decrease time,and peak intensity for differential diagnosis of NETLM were 0.549,0.657,0.809,and 0.777,respectively,and the area under the curve of combined diagnosis was 0.945,which was statistically significant compared with the individual diagnosis of each parameter(Z=2.172,3.728,2.172,2.469,all P<0.05).All 29 NETLM patients successfully completed contrast-enhanced ultrasound-guided ablation,26 patients were completely inactivated by only one ablation,2 patients were completely inactivated by 2 ablations,and 1 patient received chemotherapy intervention after ablation to achieve inactivation.Conclusion success rate of one-time ablation.
作者
梁娴
符慧
黄利
LIANG Xian;FU Hui;HUANG Li(Department of Ultrasound,the First Affiliated Hospital of Hainan Medical University,Haikou 570102,China)
出处
《临床超声医学杂志》
CSCD
2022年第6期427-430,共4页
Journal of Clinical Ultrasound in Medicine
关键词
超声检查
造影剂
神经内分泌肿瘤
肝转移
消融
Ultrasonography
Contrast agent
Neuroendocrine tumors
Liver metastases
Ablation
