摘要
目的糖尿病早期肾损伤的诊断中应用尿糖联合尿微量白蛋白检验的价值分析。方法选取2017年1月—2018年1月在该院就诊的高度疑似糖尿病早期肾损伤患者80例为观察组,并选取同期在该院就诊的不存在早期肾损伤的糖尿病患者50例为对照1组,再选取同期在该院接受体检的健康人群50名为对照2组。所有受检者均接受尿糖联合尿微量白蛋白检验,对比3组受检人员的尿糖及尿微量白蛋白水平差异情况。以高度疑似糖尿病早期肾损伤患者的肾小球滤过率监测结果为金标准,对比单一尿糖检验、单一尿微量白蛋白检验及两种方式联合检验对糖尿病早期肾损伤的阳性检出率、诊断准确度、诊断灵敏度、诊断特异度情况。结果观察组患者的尿糖及尿微量白蛋白水平显著高于对照1组及对照2组的尿糖及尿微量白蛋白水平,差异有统计学意义(P<0.05);对照1组患者的尿糖及尿微量白蛋白水平显著高于对照2组受检者的尿糖及尿微量白蛋白水平,差异有统计学意义(P<0.05);80例高度疑似糖尿病早期肾损伤患者中,经肾小球滤过率监测最终确诊为糖尿病早期肾损伤患者有75例,有56例患者尿糖检验结果阳性,有64例患者尿微量白蛋白检验结果阳性,有73例患者尿微量白蛋白和尿糖联合检验结果阳性;联合诊断结果准确度、特异度与敏感度显著高于单一尿糖检验及单一尿微量白蛋白检验诊断结果的准确度、特异度与敏感度,差异有统计学意义(P<0.05);单一尿微量白蛋白检验诊断结果准确度、特异度与敏感度显著高于单一尿糖检验诊断结果的准确度、特异度与敏感度,差异有统计学意义(P<0.05)。结论糖尿病早期肾损伤的诊断中应用尿糖联合尿微量白蛋白检验价值显著,灵敏度、特异度、准确率均较高,且伴有早期肾损伤的糖尿病患者尿糖及尿微量白蛋白检验水平显著高于不存在早期肾损伤的糖尿病患者。
Objective To analyze the value of urine glucose combined with urine microalbumin test in the diagnosis of early diabetic kidney injury.Methods 80 patients with highly suspected early diabetic kidney injury who were treated in the hospital from January 2017 to January 2018 were selected as the observation group.Fifty diabetic patients without early kidney injury who were treated in the hospital during the same period were selected as the control group 1,and 50 healthy people who received physical examination in the hospital during the same period were selected as the control group 2.All subjects received urine glucose combined with urine microalbumin test,and the differences in urine glucose and urine microalbumin levels were compared among the three groups of subjects.The results of glomerular filtration rate monitoring was the gold standard for the diagnosis of patients with high suspicion of early diabetic kidney injury.The positive detection rate,diagnostic accuracy,diagnostic sensitivity and diagnostic specificity of single urine glucose test,single urine microalbumin test and the combined test of the two methods for early diabetic kidney injury were compared.Results The levels of urine glucose and microalbumin in the observation group were significantly higher than those in the control group 1 and control group 2,and the differences were statistically significant(P<0.05).The levels of urine glucose and microalbumin in control group 1 were significantly higher than those in control group 2,and the difference was statistically significant(P<0.05).Among the 80 patients with highly suspected early diabetic kidney injury,75 patients were finally diagnosed with early diabetic kidney injury by glomerular filtration rate monitoring,56 patients had positive urine glucose test results,64 patients had positive urine microalbumin test results,and 73 patients had positive results in the combined test of urine microalbumin and urine sugar.The accuracy,specificity and sensitivity of the combined diagnostic results were significantly higher than the accuracy,specificity and sensitivity of the single urine glucose test and single urine microalbumin test,and the difference was statistically significant(P<0.05).The diagnostic accuracy,specificity and sensitivity of single urine microalbumin test were significantly higher than those of single urine glucose test,and the difference was statistically significant(P<0.05).Conclusion The application of urine glucose combined with urine microalbumin test in the diagnosis of early diabetic kidney injury is of significant value,with high sensitivity,specificity and accuracy.The levels of urine glucose and microalbumin in the diabetic patients with early renal injury were significantly higher than those in the diabetic patients without early renal injury.
作者
陈莉萍
CHEN Liping(Inspection Department,Fuzhou Children's Welfare Institute,Fuzhou,Fujian Province,350001 China)
出处
《糖尿病新世界》
2022年第10期1-5,共5页
Diabetes New World Magazine
关键词
糖尿病
早期肾损伤
尿糖
尿微量白蛋白
肾小球滤过率
诊断效能
Diabetes
Early kidney injury
Urine glucose
Urine microalbumin
Glomerular filtration rate
Diagnostic efficacy
