摘要
高脂血症与肾功能损伤密切相关,两者相互影响。脂质沉积于肾脏,通过直接和间接的作用,影响肾小球、肾小管的功能和结构,导致肾功能损伤。而肾功能损伤进一步影响机体脂质代谢,又加剧了高脂血症的进程。目前,除了合成药物以外,还有很多非合成药物在高脂血症动物模型肾功能损伤的干预治疗中取得了很好的疗效。本文概述近年来国内外利用高脂血症动物模型研究肾功能损伤机制及其相关干预治疗的最新进展。
Hyperlipidemia is closely related to renal function damage,and they influence each other.Lipid deposition in the kidney affects the function and structure of glomerulus and renal tubules directly and indirectly,resulting in renal function injury.On the contrary,renal function damage further affects lipid metabolism and aggravates the progress of hyperlipidemia.At present,besides synthetic drugs,there are many non-synthetic drugs which have been well verified in the intervention of kidney injury in hyperlipidemia animal model.In this paper,the research progress in the mechanism of renal function damage and the related intervention using hyperlipidemia animal model at home and abroad in recent years were summarized.
作者
周晓丽
张倩
钱智勇
ZHOU Xiaoli;ZHANG Qian;QIAN Zhiyong(Department of Toxicology,Tianjin Center for Disease Control and Prevention,Tianjin 300011,China)
出处
《实验动物与比较医学》
CAS
2022年第3期213-219,共7页
Laboratory Animal and Comparative Medicine
