摘要
目的初步调查及建立潮阳、潮南地区孕妇甲状腺功能相关指标的参考区间。方法将2019年1月至12月于汕头市潮阳区大峰医院产检的360例孕妇作为实验组,另选取同期同一医院行体检的120例健康非妊娠妇女作为对照组。采用化学发光免疫分析法检测两组的血清促甲状腺激素(TSH)、总三碘甲状腺原氨酸(TT3)、游离三碘甲状腺原氨酸(FT3)、甲状腺激素(TT4)、游离甲状腺素(FT4)的水平,建立孕妇不同妊娠期各甲状腺功能指标的参考区间。结果潮阳、潮南地区孕妇妊娠早、中、晚期TSH参考区间分别为0.05~5.54mIU/L、0.07~4.12mIU/L、0.19~6.03mIU/L,TT3为1.15~2.89nmol/L、1.30~2.78nmol/L、1.12~2.67nmol/L,FT3为3.41~5.87pmol/L、3.00~5.02pmol/L、2.29~4.66pmol/L,TT4为65.29~170.09nmol/L、77.52~171.21nmol/L、8.01~14.52nmol/L,FT4为11.42~18.68pmol/L、9.10~16.33pmol/L、7.95~14.28pmol/L。妊娠期妇女血清TSH、TT3、FT3、TT4、FT4水平与非妊娠期比较,差异具有统计学意义(H=42.873、139.462、227.527、195.451、330.481,P<0.01)。结论妊娠期妇女甲状腺功能相关指标水平与非妊娠期不同,因此建立本地区不同妊娠时期血清甲状腺功能相关指标的参考区间,有助于及时判断妊娠期妇女甲状腺功能的异常。
Objective To preliminary investigate and establish the reference interval of thyroid function related indicators of pregnancy women in Chaoyang and Chaonan.Methods A total of 360 pregnant women who underwent physical examination in Shantou Chaoyang District Dafeng Hospital from January to December 2019 were selected as the experimental group,and 120 healthy non-pregnant women who underwent physical examination in the same hospital during the same period were selected as the control group.The serum levels of thyroid stimulating hormone(TSH),total triiodothyronine(TT3),free triiodothyronine(FT3),thyroid hormone(TT4)and free thyroxine(FT4)in the two groups were detected by chemiluminescence immunoassay,and the reference intervals of thyroid function indexes in different stages of pregnancy were established.Results In Chaoyang and Chaonan,the TSH in the early,middle and late stages of pregnancy were 0.05-5.54 mIU/L,0.07-4.12 mIU/L,0.19-6.03 mIU/L;TT3 were 1.15-2.89 nmol/L,1.30-2.78 nmol/L,1.12-2.67 nmol/L;FT3 were 3.41-5.87 pmol/L,3.00-5.02 pmol/L,2.29-4.66 pmol/L;TT4 were 65.29-170.09 nmol/L,77.52-171.21 nmol/L,8.01-14.52 nmol/L;FT4 were 11.42-18.68 pmol/L,9.10-16.33 pmol/L,7.95-14.28 pmol/L.There were significant differences in serum TSH,TT3,FT3,TT4,FT4 between pregnant women and non-pregnant women(H=42.873,139.462,227.527,195.451,330.481,P<0.01).Conclusions The level of thyroid function indexes in pregnant women is different from that in non-pregnant women,so the establishment of reference value range of serum thyroid function indexes in different gestational periods is conducive to timely diagnose the thyroid dysfunction in pregnant women.
作者
范进绵
黄燕芬
梁燕红
郭钊林
王佳蓉
FAN Jinmian;HUANG Yanfen;LIANG Yanhong;GUO Zhaolin;WANG Jiarong(Department of Secretory,Shantou Chaoyang District Dafeng Hospital,Shantou515154,Guangdong,China;Department of Laboratory,Shantou Chaoyang District Dafeng Hospital,Shantou515154,Guangdong,China;Department of Obstetrics,Shantou Chaoyang District Dafeng Hospital,Shantou515154,Guangdong,China)
出处
《中国性科学》
2022年第6期43-46,共4页
Chinese Journal of Human Sexuality
基金
汕头市科技计划医疗卫生项目(190923155260433)。
关键词
孕妇
妊娠期
甲状腺功能
参考区间
Pregnant women
Gestational period
Thyroid function
Reference interval
