摘要
目的:比较那曲肝素钙注射液和磺达肝癸钠注射液预防骨科手术后静脉血栓栓塞症(VTE)的药物经济学评价。方法:回顾性分析2020年1月至2021年10月景德镇市第二人民医院收治的90例骨科手术患者的病历资料,根据术后不同干预方法分为两组,观察组和对照组各45例。对照组行那曲肝素钙注射液预防性治疗,观察组行磺达肝癸钠注射液预防性治疗,比较两组患者凝血功能指标、不良事件及临床相关指标、药物经济学。结果:治疗后,两组患者血小板计数(PLT)、凝血活酶时间(APTT)、纤维蛋白原(FIB)、D-二聚体(D-D)水平比较,差异无统计学意义(P>0.05),观察组患者抗凝血酶Ⅲ(AT-Ⅲ)低于对照组(P<0.05);两组患者不良事件发生率比较,差异无统计学意义(P>0.05);那曲肝素钙注射液总成本为723.80元,总有效率为86.67%,药物治疗成本比(C/E)=8.35,磺达肝癸钠注射液总成本为1862.00元,总有效率为93.33%,C/E=19.95,那曲肝素钙注射液费用及C/E均低于磺达肝癸钠注射液(P<0.05)。结论:预防骨科手术后VTE采用那曲肝素钙注射液和磺达肝癸钠注射液效果相当,均具备较高应用价值,且磺达肝癸钠药理作用更具优势;在药物治疗成本上,那曲肝素钙则较为经济。
Objective:To compare the pharmacoeconomic evaluation of nadroparin calcium injection and fondaparinux sodium injection in preventing venous thromboembolism(VTE)after orthopedic surgery.Methods:The medical records of 90 patients with orthopaedic surgery who were admitted to The Second People's Hospital of Jingdezhen from January 2020 to October 2021 were retrospectively analyzed.According to different postoperative intervention methods,they were divided into two groups,the observation group and the control group,with 45 cases in each.The control group received nadroparin calcium injection prophylactic treatment,and the observation group received fondaparinux sodium injection prophylactic treatment.The coagulation function indexes,adverse events,clinical related indexes,and pharmacoeconomics were compared between the two groups.Results:After treatment,the levels of platelet count(PLT),thromboplastin time(APTT),fibrinogen(FIB)and D-dimer(D-D)between the two groups were compared(P>0.05).(AT-Ⅲ)was lower than the control group(P<0.05).The incidence of adverse events in the two groups were compared(P>0.05).The cost of nadroparin calcium injection total cost was 723.80 yuan,and the total effective rate was 86.67%,the drug treatment cost ratio(C/E)=8.35,the cost of fondaparinux sodium injection total cost was 1862.00 yuan,and the total effective rate was 93.33%,C/E=19.95.The cost and C/E of nadroparin calcium injection were lower than those of fondaparinux sodium injection(P<0.05).Conclusion:The effect of nadroparin calcium injection and fondaparinux sodium injection on prevention of VTE after orthopedic surgery is similar,both have high application value,and fondaparinux sodium injection is more advantageous pharmacological action.In the cost of drug treatment,nadroparin calcium injection is more economical.
作者
邵梦莉
郑凡
钟善清
SHAO Mengli;ZHENG Fan;ZHONG Shanqing(The Second People's Hospital of Jingdezhen,Jingdezhen Jiangxi 333000,China.)
出处
《药品评价》
CAS
2022年第8期483-486,共4页
Drug Evaluation
基金
景德镇市科技计划项目(20211SFZC045)。
关键词
抗凝药
静脉血栓栓塞
手术后并发症
关节成形术
置换
髋
那曲肝素钙注射液
磺达肝癸钠注射液
骨科手术
凝血功能
Anticoagulants
Venous thromboembolism
Postoperative complications
Arthroplasty,replacement,hip
Nadroparin calcium injection
Fondaparinux sodium injection
Orthopaedic surgery
Coagulation function
