摘要
目的:研究小剂量肉毒毒素联合光疗治疗的雄激素源性脱发的临床疗效观察。方法:选取2019年1月-2020年10月笔者医院收治的75例雄激素源性脱发患者,采用随机数字表法分为实验组(n=37)和对照组(n=38),对照组仅给予光疗和传统米诺地尔酊治疗,实验组在对照组的基础上给予小剂量肉毒毒素治疗。对比两组患者治疗前后3、6个月时头皮症状评分、毛发镜指数;对比两组治疗6个月后临床疗效和治疗期间出现的不良反应。结果:治疗后,随着时间变化,两组患者头屑评分、瘙痒评分均降低,且相比于对照组,实验组头屑评分、瘙痒评分更低(P<0.05);治疗后,随着时间变化,两组患者毛囊密度、被毛密度均升高,且相比于对照组,实验组毛囊密度、被毛密度更高(P<0.05);相比于对照组总有效率76.31%(29/38),实验组总有效率94.59%(35/37)更高(P<0.05);对照组不良反应发生率2.63%(1/38)与实验组不良反应发生率5.40%(2/37)相比差异不具有统计学意义(P>0.05)。结论:小剂量肉毒毒素联合光疗的雄激素源性脱发的临床疗效较好,能够有效改善患者的头症状和头发密度以及脱发症状,且无不良反应的发生,安全性较高。
Objective To study the clinical efficacy of low-dose botulinum toxin combined with phototherapy in the treatment of androgenic alopecia.Methods Seventy-five patients with androgenic alopecia admitted to author hospital from January 2019 to October 2020 were selected and divided into experimental group (n=37) and control group (n=38) by random number table method.The control group only received phototherapy treatment and traditional minoxidil tincture treatment,and the experimental group received low-dose botulinum toxin treatment on the basis of the control group.The scalp symptom score and the hair mirror index before and 3,6 months after treatment as well as the clinical efficacy after 6 months of treatment and the adverse reactions during the treatment period were compared between the two groups.Results After treatment,the dandruff score and the pruritus score of the two groups decreased over time,and compared with the control group,the dandruff score and the the pruritus score of the experimental group were significantly lower (P<0.05).After treatment,the hair follicle density and the coat density of the two groups of patients increased over time,and compared with the control group,the hair follicle density and the coat density of the experimental group were significantly higher (P<0.05).Compared with the control group[76.31 % (29/38)],the total effective rate of the experimental group[94.59% (35/37)]was significantly higher (P<0.05)].The adverse reaction rate of the control group was 2.63% (1/38) and that of the experimental group was 5.40% (2/37) without significant difference (P>0.05).Conclusion The clinical efficacy of low-dose botulinum toxin combined with phototherapy for androgenic alopecia is good,which can effectively improve the patients’ head symptoms and hair loss with no adverse reactions and high safety.
作者
王洁
何振兴
赵菊花
李娜
WANG Jie;HE Zhenxing;ZHAO Juhua;LI Na(Department of Dermatology,Nanchong Central Hospital,Nanchong 637000,Sichuan,China;Department of Hepatobiliary Surgery,Nanchong Central Hospital,Nanchong 637000,Sichuan,China)
出处
《中国美容医学》
CAS
2022年第6期5-8,共4页
Chinese Journal of Aesthetic Medicine
关键词
小剂量
肉毒毒素
光疗
雄激素源性脱发
临床疗效
low dose
botulinum toxin
phototherapy
androgenic alopecia
clinical efficacy
