摘要
目的 探讨外周血甲状腺激素(TH)水平对青少年非自杀性自伤行为(NSSI)的影响,以及TH水平与HAMD-24评分的相关性.方法 选取符合NSSI诊断的青少年患者82例(NSSI组);同期体检健康的青少年81例为对照组.比较两组外周血TH水平,并分析单相抑郁症、双相抑郁症外周血TH水平与HAMD-24评分的相关性.结果 NSSI组与对照组外周血促甲状腺激素(TSH)、T_(3)、T4、FT_(3)、FT_(3)/FT4水平比较,差异均有统计学意义(P<0.05),而FT4水平比较差异无统计学意义(P>0.05);单相抑郁组与双相抑郁组外周血TH水平比较差异无统计学意义(P>0.05).单相抑郁症患者外周血TSH水平与HAMD-24评分呈负相关(r=-0.405,P<0.001).双相抑郁症患者外周血T4水平与HAMD-24评分呈正相关(r=0.335,P<0.05).逐步回归分析显示,抑郁组中,TSH进入以HAMD-24为因变量的回归方程,TSH可以解释HAMD-24变异的14.2%.结论 青少年NSSI患者外周血TH水平比健康对照者明显降低.
Objective To investigate the efet of peripheral blood thyroid hormone level on adolescent non-suicidal self-injury behavior(NSSI),and the correltion between TH level and Hamiton Depression Scale 24-item score(HAMD-24).Methods A total of 82 adolescent patients with dSM-5 non-suicidal NSSI who were hospitalized in the Department of Clinical Psychology of Zhejiang Provincial People's Hospial from November 2018 to May 2021 were selected a the NSSI group.During the same period,81 healthy adolescents underwent physical examination in hospital were selected as the control group.The TH level in peripheral blood of NSSI group and healthy control group was compared,and the correlation between TH level in peripheral blood of monophasic depression and bipolar depression paticnts and HAMD-24 score was analyzed respectively.Results There were stistically significant diferences in TSH,T_(3),T4,FT_(3) and FT_(3)/FT4 levels between NSSI group and healthy control group(P<0.05),but there was no staistically significant diference in FT4 level between NSSI group and healhy control group(P>0.05).There was no significant diference in TH level in peripheral blood between unipolar depression group and bipolar depression group(P>0.05).There was a negative correlation between TSH level and HAMD-24 score(r=-0.405,P<0.001).The level of T4 in peripheral blood of patients with bipolar depression was positively correlated with HAMD-24 score(r=0.335,P<0.05).Stepwise regression analysis showed that IN the depression group,TSH entered the regression equation with HAMD-24 as the dependent variable,and TSH could explain 14.2%of the variation in HAMD-24.Conclusion The level of TH in peripheral blood of adolescent NSSI patients is significantly lower than that of healthy controls.
出处
《浙江临床医学》
2022年第5期687-689,共3页
Zhejiang Clinical Medical Journal
关键词
非自杀性自伤
青少年
甲状腺激素
Non-suicidal self-injury
Teenagers
Thyroid hormone
