摘要
目的:探讨血清白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)、脂蛋白相关磷脂酶A2(Lp-PLA2)水平检测在急性冠状动脉综合征(ACS)患者冠状动脉微血管障碍(MVD)诊断中的应用价值。方法:回顾性分析2019年10月至2020年8月该院收治的83例ACS患者的临床资料,按是否合并MVD分为ACS合并MVD组21例和ACS未合并MVD组62例,另选取40名同期健康体检者作为对照组。比较三组IL-6、hs-CRP、Lp-PLA2水平,并绘制受试者工作特征曲线(ROC),分析血清IL-6、hs-CRP、Lp-PLA2水平单项及联合检测诊断ACS合并MVD的价值。结果:ACS合并MVD组血清IL-6、hs-CRP、Lp-PLA2水平均高于ACS未合并MVD组和对照组,且ACS未合并MVD组高于对照组,差异有统计学意义(P<0.05);ROC曲线结果分析显示,ACS患者血清IL-6、hs-CRP、Lp-PLA2水平单项及联合检测诊断ACS合并MVD的曲线下面积(AUC)分别为0.812、0.781、0.828、0.878,均具有一定的诊断价值,且联合检测诊断的AUC大于单项检测,诊断价值更理想。结论:ACS合并MVD患者IL-6、hs-CRP、Lp-PLA2水平呈高表达,血清IL-6、hs-CRP、Lp-PLA2水平检测应用于ACS患者MVD诊断具有较高诊断价值。
Objective: To investigate application value of detection of serum interleukin-6(IL-6), high sensitivity C-reactive protein(hs-CRP) and lipoprotein-related phospholipase A2(Lp-PLA2) levels in coronary microvascular disorders(MVD) in patients with acute coronary syndrome(ACS). Methods: The clinical data of 83 ACS patients admitted to our hospital from October 2019 to August 2020 were retrospectively analyzed.According to whether the patients were combined with MVD or not, they were divided into ACS combined with MVD group(21 cases) and ACS combined with non-MVD group(62 cases). Another 40 healthy subjects were selected as control group. The levels of IL-6, hs-CRP and Lp-PLA2were compared among the three groups. The receiver operating characteristic(ROC) curve was plotted, and the values of serum IL-6, hs-CRP and LpPLA2 levels in the diagnosis of ACS complicated with MVD were analyzed. Results: The serum levels of IL-6, hs-CRP and Lp-PLA2 in the ACS combined with MVD group were higher than those in the ACS combined with non-MVD group and the control group, those of the ACS combined with non-MVD group were higher than those of the control group, and the differences were statistically significant(P<0.05). The ROC curve analysis showed that the AUCs of the serum IL-6, hs-CRP and Lp-PLA2 levels in the patients with ACS for the diagnosis of ACS combined with non-MVD were 0.812, 0.781, 0.828, and 0.878, separately, all of which had certain diagnostic value. The AUC of the combined detection was greater than that of single detection, and its diagnostic value was more ideal. Conclusions: The levels of IL-6, hs-CRP and Lp-PLA2 are highly expressed in the patients with ACS complicated with MVD. The detection of serum IL-6, hs-CRP and Lp-PLA2 levels has high diagnostic value in the diagnosis of MVD in the patients with ACS.
作者
林泽强
谭丹
LIN Zeqiang;TAN Dan(Nanhai Hospital of Southern Medical University,Department of Laboratory Medicine,Foshan 528244 Guangdong,China;Nanhai Hospital of Southern Medical University,Department of Pediatrics,Foshan 528244 Guangdong,China)
出处
《中国民康医学》
2022年第11期130-132,共3页
Medical Journal of Chinese People’s Health
基金
广东省佛山市卫生健康局医学科研课题项目(20210361)。
