摘要
目的分析郑州市流感监测哨点医院病原学监测结果,了解儿童专科医院和综合医院在流感病原学监测中的特点,为提高流感实验室监测质量提供参考。方法选择2016年4月1日至2019年12月31日,按照《全国流感监测方案》要求,郑州市流感监测哨点医院(郑州市儿童医院和某综合医院),每周采集流感样病例咽拭子,提取病毒RNA,应用实时荧光RT-PCR方法进行检测,并对检测结果进行统计分析。结果共采集流感样病例标本4730份,阳性1128份,阳性率23.84%,其中,儿童医院和综合医院阳性率分别为23.48%和24.21%,差异无统计学意义(χ^(2)=0.342,P>0.05)。2016和2019年阳性率最低和最高分别为6.61%和37.16%,不同年份间阳性率差异有统计学意义(χ^(2)=105.943,P<0.05),2019年儿童医院阳性率34.29%低于综合医院39.97%(χ^(2)=4.646,P<0.05)。儿童医院0~4岁阳性率17.91%高于综合医院11.41%(χ^(2)=11.678,P<0.05),5~14岁阳性率42.88%高于综合医院27.83%(χ^(2)=18.686,P<0.05),两家医院5~14岁阳性率均高于本院的0~4岁组;综合医院≥60岁年龄组阳性率最高(32.41%),各年龄组间阳性率差异有统计学意义(χ^(2)=56.639,P<0.05)。两家医院流感样病例标本阳性数及阳性率均呈典型的季节性分布,阳性率高峰出现时间较为一致。结论儿童专科医院与综合医院流感样病例标本阳性率无差异,但儿童专科医院0~4岁和5~14岁阳性率均高于综合医院,加强综合医院小年龄组流感样病例标本采集质量将是今后哨点医院工作重点。
Objective By comparing and analyzing the results of etiological surveillance of influenza viruses in children’s specialist hospital and general hospital in Zhengzhou,to understand the influenza epidemic pattern and provide a basis for scientific and effective prevention and control of influenza.Methods In accordance with the requirements of National Influenza Surveillance Program,pharyngeal swabs of influenza-like illness(ILI)were collected weekly from two influenza surveillance sentinel hospitals(one each from children’s hospital and general hospital)in Zhengzhou,and viral RNA was extracted and tested by real-time fluorescence RT-PCR method from April 1,2016 to December 31,2019.Statistical analysis of the test results was performed.Results A total of 4730 specimens were tested,with a positive rate 23.84%,of which 23.48%in children’s hospital and 24.21%in general hospital,with no statistically significant difference(χ~2=0.342,P>0.05).In 2016 and 2019,the lowest and highest positive rates were 6.61%and 37.16%,respectively,and there was a statistically significant difference in positive rates between different years(χ~2=105.943,P<0.05).In 2019,the positive rate of children’s hospital was 34.29%,which was lower than that of general hospital(39.97%)(χ~2=4.646,P<0.05).The positive rate of children’s hospital aged 0-4 was 17.91%,which was higher than that of general hospital(11.41%)(χ~2=11.678,P<0.05),and the age group 5-14 years(42.88%)was higher than that of general hospital(27.83%)(χ~2=18.686,P<0.05).The positive rates of age group 5-14 years in the two hospitals were both higher than that of 0-4 years;the positive rate of aged≥60-year-old in the general hospital was the highest(32.41%),and the difference in the positive rate between the age groups was statistically significant(χ~2=56.639,P<0.05).The positive number and positive rate of influenza-like cases in the two hospitals showed typical seasonal distribution,and the peak time of positive rate was relatively consistent.Conclusion There is no difference in the positive rate of influenza surveillance between children’s specialized hospitals and general hospitals,but the positive rates of age group 0-4 years and 5-14 years in children’s hospital are higher than those in general hospital.Strengthening the quality of influenza surveillance in general hospital is the focus.Strengthening the quality of specimen collection of influenza surveillance in general hospitals in younger age groups will be the focus.
作者
程春荣
胡乃月
王治国
王琳
张航
CHENG Chunrong;HU Naiyue;WANG Zhiguo;WANG Lin;ZHANG Hang(Zhengzhou Center for Disease Control and Prevention,Zhengzhou 450007,China)
出处
《河南预防医学杂志》
2022年第6期409-413,共5页
Henan Journal of Preventive Medicine
关键词
流感监测
儿童流感
病原学监测
Influenza surveillance
Influenza in children
Pathogenetic surveillance
