摘要
目的探讨子痫前期(PE)及其严重程度对妊娠期和分娩后孕妇血清尿酸、中性粒细胞明胶酶相关脂质运载蛋白(NGAL)和肾损伤分子-1(KIM-1)水平的影响。方法选取2019年8月至2020年12月该院收治的81例PE孕妇纳入研究,根据严重程度分为轻度PE组和重度PE组。另外,选取同期于该院进行孕检的80例血压正常的单胎妊娠女性作为对照组。在入组时及分娩后42 d、3个月、6个月时测定各组孕妇血清尿酸、NGAL和KIM-1水平。比较3组血清尿酸、NGAL、KIM-1水平并分析变化趋势。结果轻度PE组和重度PE组患者入组时血清尿酸、NGAL、KIM-1、BUN、肌酐水平均高于对照组(P<0.05),且重度PE组患者尿酸、NGAL、KIM-1水平高于轻度PE组(P<0.05)。3组组内各个时间点间血清尿酸、NGAL、KIM-1水平比较,差异均有统计学意义(P<0.05)。分娩后42 d、3个月、6个月时,重度PE组血清尿酸、NGAL、KIM-1水平均高于对照组(P<0.05)。结论对于重度PE患者而言,妊娠期间所造成的肾脏损害会持续到产后6个月。
Objective To investigate the effect of preeclampsia(PE)and its severity on the levels of serum uric acid,neutrophil gelatinase-associated lipocalin(NGAL)and kidney injury molecule-1(KIM-1)in pregnant women during and after delivery.Methods A total of 81 pregnant women with PE admitted to the hospital from August 2019 to December 2020 were enrolled in the study,and they were divided into mild PE group and severe PE group according to the severity.In addition,80 women with singleton pregnancy and normal blood pressure who underwent pregnancy examination in the hospital during the same period were enrolled as the control group.The serum uric acid,NGAL and KIM-1 levels of pregnant women in each group were measured at the time of enrollment and at 42 days,3 months,and 6 months after delivery.The levels of serum uric acid,NGAL and KIM-1 in the three groups were compared and the change trend was analyzed.Results The levels of uric acid,NGAL,KIM-1,BUN and creatinine in mild PE group and severe PE group were higher than those in control group(P<0.05),and the levels of uric acid,NGAL,KIM-1 in severe PE group were higher than those in mild PE group(P<0.05).The levels of serum uric acid,NGAL and KIM-1 in the three groups were compared among different time points,and the differences were statistically significant(P<0.05).At 42 days,3 months and 6 months after delivery,the levels of serum uric acid,NGAL and KIM-1 in the severe PE group were higher than those in the control group(P<0.05).Conclusion In patients with severe PE,kidney damage during pregnancy persists until 6 months postpartum.
作者
李聪
陈茜松
LI Cong;CHEN Qiansong(Department of Obstetrics,Shijiazhuang Maternal and Child Health Hospital,Shijiazhuang,Hebei 050000,China)
出处
《国际检验医学杂志》
CAS
2022年第13期1567-1571,共5页
International Journal of Laboratory Medicine
基金
河北省重点研发计划自筹项目课题(182777175)。
