摘要
目的探讨通阳宣痹汤治疗痰瘀互结型稳定型心绞痛(SAP)的临床效果。方法将2020年10月至2021年4月在我院进行治疗的500例痰瘀互结型SAP患者根据不同的治疗方案分为西医组(n=250,西药)和综合组(n=250,在西医组的基础上增加通阳宣痹汤)。比较两组的治疗效果。结果用药后,两组的一氧化氮(NO)水平及血流介导的血管扩张功能(FMD)较用药前升高,内皮素-1(ET-1)水平较用药前降低,且综合组优于西医组(P<0.05)。用药后,两组的西雅图心绞痛量表(SAQ)三个维度评分较用药前升高,且综合组高于西医组(P<0.05)。综合组的治疗总有效率高于西医组(P<0.05)。用药后,两组的冠脉血流速度储备(CFVR)、左前降支舒张期峰流速(DPV)、左前降支收缩期峰流速(SPV)、舒张期时间速度积分(CTVI)较用药前升高,且综合组高于西医组(P<0.05)。用药后,两组的左室舒张末内径(LVDd)、左室收缩末内径(LVDs)较用药前减小,左心射血分数(LVEF)及心脏指数(CI)较用药前升高,且综合组优于西医组(P<0.05)。结论通阳宣痹汤治疗痰瘀互结型SAP的临床效果显著,能抑制各种SAP症状,也能发挥保护血管、改善冠脉血流参数以及促进心功能恢复的作用。
Objective To investigate clinical effect of Tongyang Xuanbi decoction in the treatment of stable angina pectoris(SAP)of phlegm-blood stasis type.Methods A total of 500 SAP patients of phlegm-blood stasis type who received treatment in our hospital from October 2020 to April 2021 were divided into western medicine group(n=250,western medicine)and comprehensive group(n=250,Tongyang Xuanbi decoction on the basis of the western medicine group)according to different treatment schemes.The therapeutic effects of the two groups were compared.Results After medication,the level of nitric oxide(NO)and flow-mediated dilation(FMD)in the two groups were higher than those before treatment,the level of endothelin-1(ET-1)was lower than that before treatment,and those in the comprehensive group were better than the western medicine group(P<0.05).After medication,the three dimension scores of Sesttle angina questionnaire(SAQ)in the two groups were higher than those before treatment,and those in the comprehensive group were higher than the western medicine group(P<0.05).The total effective rate of treatment in the comprehensive group was higher than that in the western medicine group(P<0.05).After medication,the coronary flow velocity reserve(CFVR),diastolic peak velocity(DPV),systolic peak velocity(SPV)and diastolic time velocity integral(CTVI)in the two groups were higher than those before treatment,and those in the comprehensive group were higher than the western medicine group(P<0.05).After medication,the left ventricular end diastolic diameter(LVDd)and left ventricular end systolic diameter(LVDs)of the two groups were smaller than those before treatment,the left ventricular ejection fraction(LVEF)and cardiac index(CI)were higher than those before treatment,and those of the comprehensive group were better than the western medicine group(P<0.05).Conclusion Tongyang Xuanbi decoction in the treatment of SAP of phlegm-blood stasis type has a significant clinical effect,it can not only inhibit various SAP symptoms,but also protect blood vessels,improve coronary blood flow parameters and promote the recovery of cardiac function.
作者
闫琼琼
朱华
YAN Qiongqiong;ZHU Hua(Cardiovascular Medicine Department,the Second People's Hospital of Xinzheng,Xinzheng 451100;Radiology Department,Puyang Oilfield General Hospital,Puyang 457001,China)
出处
《临床医学研究与实践》
2022年第20期135-138,共4页
Clinical Research and Practice
关键词
冠脉粥样硬化
痰瘀互结型
通阳宣痹汤
稳定型心绞痛
coronary atherosclerosis
phlegm-blood stasis type
Tongyang Xuanbi decoction
stable angina pectoris
