摘要
目的探讨肿瘤标志物联合MRI成像对卵巢交界性肿瘤的定性诊断价值。方法选取2015年1月~2020年1月厦门市第五医院收治的90例卵巢囊性肿物患者为研究对象,根据肿瘤性质分为良性肿瘤组(n=30)和交界性肿瘤组(n=60),均常规行MRI多期动态增强扫描,并结合血清肿瘤标志物水平进行综合分析。结果66.67%交界性卵巢肿瘤患者存在实性成分,而只有3.33%的良性肿瘤患者存在实性成分(P<0.05)。交界性卵巢肿瘤患者的CA125(中位数,43.81 U/ml)明显高于良性肿瘤组(P<0.05)。61.67%的卵巢交界性肿瘤患者分房数超过5,而只有33.33%的良性肿瘤患者分房数超过5(P<0.05)。肿瘤标志物联合MRI扫描对卵巢交界性肿瘤的阳性检出率为93.33%,显著高于单独MRI的阳性检出率(χ^(2)=4.615,P=0.032)。ROC曲线分析也进一步证实MRI联合肿瘤标志物CA125对卵巢交界性肿瘤诊断价值更大(ROC曲线下面积为0.845,P=0.012)。结论肿瘤标志物CA125联合MRI成像有利于更好地鉴别卵巢交界性肿瘤和卵巢良性囊肿。
Objective To investigate the value of tumor markers combined with magnetic resonance imaging(MRI)in the qualitative diagnosis of borderline ovarian tumors.Methods A total of 90 patients with ovarian cystic tumors who were admitted to the Fifth Hospital of Xiamen from January 2015 to January 2020 were selected as the research objects and divided into the benign tumor group(n=30)and the borderline tumor group(n=60)according to tumor properties.All patients underwent routine MRI multi-phase dynamic contrast-enhanced scanning,and the serum tumor marker levels were combined for comprehensive analysis.Results 66.67%of patients with borderline ovarian tumors had solid components,while only 3.33%of patients with benign tumors had solid components(P<0.05).The CA125 of the borderline ovarian tumor group(median,43.81 U/ml)was significantly higher than that of the benign tumor group(P<0.05).61.67%of patients with borderline ovarian tumors had more than 5 tumor compartments,while only 33.33%of patients with benign tumors had more than 5 tumor compartments(P<0.05).The positive detection rate of tumor markers combined with MRI scanning for borderline ovarian tumors was 93.33%,which was significantly higher than that of MRI alone(χ^(2)=4.615,P=0.032).The ROC curve analysis further confirmed that MRI combined with tumor marker CA125 had a greater diagnostic value for borderline ovarian tumors(area under the ROC curve was 0.845,P=0.012).Conclusion The combination of tumor marker CA125 and MRI imaging is beneficial to better distinguish between borderline ovarian tumors and benign ovarian cysts.
作者
陈文锦
杨加荣
洪环得
郑义
CHEN Wenjin;YANG Jiarong;HONG Huande;ZHENG Yi(Department of Radiology,the Fifth Hospital of Xiamen,Xiamen 361101,China)
出处
《中国现代医生》
2022年第18期149-152,共4页
China Modern Doctor
