摘要
A组轮状病毒(group A rotavirus,RVA)是5岁以下婴幼儿非细菌性急性胃肠炎最主要的病原体之一。RVA感染所导致的腹泻给全球婴幼儿带来了巨大的疾病负担,目前针对RVA没有特效治疗药物,只能通过接种疫苗来达到预防目的。疫苗的有效性与RVA基因型密切相关,因此,本文对国内外RVA分子分型特点的最新进展进行总结,提供基因型多样性的重要信息,为当前和未来疫苗研制中毒株基因型的选择提供参考。
Group A rotavirus(RVA)is one of the most important pathogens of non-bacterial acute gastroenteritis in infants and children under 5 years of age,and diarrhea caused by RVA infection poses a huge disease burden to infants and children worldwide.The effectiveness of vaccines is closely related to RVA genotypes;therefore,this paper summarizes the recent progress in molecular typing characteristics of RVA at home and abroad to provide important information on genotypic diversity and a reference for the selection of virulent strain genotypes in current and future vaccine development.
作者
熊光萍
李丹地
Xiong Guangping;Li Dandi(National Institute for Viral Disease Control and Prevention,Chinese Center for Disease Control and Prevention,NHC Key Laboratory of Medical Virology and Viral Diseases,National Institute for Viral Disease Control and Prevention,Beijing 102206,China)
出处
《中华实验和临床病毒学杂志》
CAS
CSCD
2022年第2期239-242,共4页
Chinese Journal of Experimental and Clinical Virology
基金
国家自然科学基金(21934005)。
