摘要
回顾性分析163例系统性硬化症(SSc)患者的临床资料,分析其类型、临床表现、实验室检查及治疗的特点,增加对该罕见病的认识。结果示本组病例中dcSSc 95例,lcSSc 49例,重叠综合征14例,UCTD 4例和sine scleroderma 1例。皮肤表现包括肿胀(18例),硬化(106例),萎缩(11例)。SSc患者163例平均mRSS评分12.0。全身各器官系统均有不同程度受累,雷诺现象最多见(51.0%)。多因素logistic回归分析示球蛋白升高是SSc累及血液系统的独立危险因素。150例患者使用糖皮质激素联合抗风湿药(DMARDs)治疗,13例使用糖皮质激素联合DMARDs及托珠单抗治疗,有一定疗效。
The data of 163 patients with systemic sclerosis(SSc)were analyzed retrospectively,including subtype,clinical manifestation and treatment.Of 163 patients,95 were dcSSc,49 were lcSSc,14 were overlap syndrome,4 were UCTD,1 was sine scleroderma.The dermatologic manifestations included swelling(18 cases),hardening(106 cases),atrophy(11 cases).The average score of mRSS(the modified Rodnan skin score)was 12.0.Many organ systems were affected and Raynaud phenomenon(51.0%)was the most common.Multivariate logistic regression showed the high level of globulin was an independent risk factor of SSc involved hematologic system.150 patients were treated with glucocorticoid combined with disease-modifying antirheumatic drugs(DMARDs)and 13 patients were treated with glucocorticoid combined with DMARDs and tocilizumab and those method showed some efficacy.
作者
蔡金云
傅萍
孙瑞希
寸杏珠
熊瑞芳
CAI Jinyun;FU Ping;SUN Ruixi;CUN Xingzhu;XIONG Ruifang(Department of Rheumatology,The Second Affiliated Hospital of Kunming Medical University,Kunming 650101,China;Department of Rheumatology,Panzhihua Central Hospital,Panzhihua 617000,China)
出处
《中国麻风皮肤病杂志》
2022年第9期589-593,共5页
China Journal of Leprosy and Skin Diseases
基金
国家自然科学基金资助项目(编号:81860287)。
