摘要
背景:脊髓缺血再灌注损伤后炎性微环境的变化影响着损伤修复和预后。目的:对脊髓缺血再灌注损伤后炎性微环境研究进展进行综述。方法:以“spinal cord ischemia-reperfusion,inflammaion,Microglia,Astrocytes,Macrophages,Crosstalk”为英文检索词,以“脊髓缺血再灌注损伤,炎症,小胶质细胞,星形胶质细胞,巨噬细胞,细胞交互”为中文检索词,检索发表在PubMed、CNKI、万方数据库的相关文献,最终纳入42篇文献进行综述分析。结果与结论:免疫炎性微环境的变化对脊髓缺血再灌注损伤后神经细胞损伤和修复具有调控作用,如小胶质细胞通过活化为M1/M2表型来调控炎症反应抵御传染源、清除凋亡和受损细胞、重塑不适当的神经连接从而帮助神经系统恢复稳态;星形胶质细胞在炎症因子的刺激下通过活化为A1/A2表型调控免疫过程来维持中枢神经系统稳态和神经元功能;以及巨噬细胞通过活化为M1/M2型来调控免疫过程修复损伤的脊髓组织,它们互相影响着彼此,如小胶质细胞和星形胶质细胞彼此也相互影响,如脊髓损伤时,小胶质细胞最先活化并释放炎症因子诱导星形胶质细胞激活,释放相应的细胞因子、趋化因子、Ca2+等来调节小胶质细胞的表型和功能,通过维持免疫炎性微环境稳态才是脊髓缺血再灌注损伤治疗的关键。
BACKGROUND:The changes in the immunoinflammatory microenvironment after spinal cord ischemia-reperfusion injury affect injury repair and prognosis.OBJECTIVE:To review the research progress in the immunoinflammatory microenvironment after spinal cord ischemia-reperfusion injury METHODS:Pub Med,CNKI,and WanFang databases were searched for relevant studies using the keywords of“spinal cord ischemia-reperfusion,inflammation,microglia,astrocytes,macrophages,crosstalk”in English and Chinese,respectively.Finally,42 relevant articles were included for further review.RESULTS AND CONCLUSION:Changes in the immunoinflammatory microenvironment can regulate nerve cell injury and repair after spinal cord ischemiareperfusion injury.For example,microglia can be differentiated into M1/M2 phenotypes to regulate inflammatory responses,resist infectious sources,remove apoptotic and damaged cells,and reshape inappropriate neural connections,thereby helping the nervous system restore homeostasis.Astrocytes can regulate immune process through differentiation into A1/A2 phenotype to maintain homeostasis in the central nervous system and neuronal function under the stimulation of inflammatory factors.Macrophages can regulate immune process and repair injured spinal cord tissue by differentiation into M1/M2 phenotype.Microglia,astrocytes and macrophages also affect each other.For example,after spinal cord injury,microglia are the first to activate and release inflammatory factors to induce the activation of astrocytes and then release corresponding cytokines,chemokines,and Ca;to regulate the phenotype and function of microglia.Maintaining the homeostasis of immunoinflammatory microenvironment is the key to the treatment of spinal cord ischemia-reperfusion injury.
作者
高煜
韩佳慧
葛新
Gao Yu;Han Jiahui;Ge Xin(Department of Intensive Care Unit,Wuxi Ninth Hospital Affiliated to Soochow University,Wuxi 214000,Jiangsu Province,China)
出处
《中国组织工程研究》
CAS
北大核心
2023年第8期1300-1305,共6页
Chinese Journal of Tissue Engineering Research
基金
无锡市卫健委精准医学重点专项(J202007),项目负责人:葛新。
