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Germline BRCA2 mutation in a case of aggressive prostate cancer accompanied by spinal bulbar muscular atrophy

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摘要 Dear Editor,Spinal and bulbar muscular atrophy(SBMA)or Kennedy’s disease is a rare X-linked,recessive,lower motor neuron disease caused by a CAG repeat expansion within the first exon of the androgen receptor(AR)gene.Instability of the CAG-triplet repeat impacts AR function;therefore,men with SBMA are thought to be at a very low risk of prostate cancer.We previously reported a case of high-risk prostate cancer with SBMA(repeat length 46).
出处 《Asian Journal of Andrology》 SCIE CAS CSCD 2022年第1期116-118,共3页 亚洲男性学杂志(英文版)
基金 Yoko Suzuki provided technical assistance.This study was supported in part by Grants-in-Aid for Scientific Research(#17K16813 to H Hongo and#17K11158 and#20H03817 to TK)from the Ministry of Education,Culture,Sports,Science,and Technology of Japan The study was supported in part by research Grant to TK from the Takeda Science Foundation,Japan。
关键词 ATROPHY MUSCULAR cancer
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