摘要
目的:统计非小细胞肺癌(NSCLC)患者的血清神经元特异性烯醇化酶(NSE)、鳞状上皮细胞癌抗原(SCCA)水平,并分析血清NSE、SCCA水平与NSCLC患者淋巴结转移的关系。方法:选择2020年6月-2021年6月某院110例NSCLC患者作为研究对象,测定NSCLC患者血清NSE、SCCA水平,统计NSCLC患者淋巴结转移发生情况,并分析血清NSE、SCCA水平与其淋巴结转移的关系。结果:经穿刺活检证实,110例NSCLC患者中有41例患者发生淋巴结转移,发生率为37.27%;发生淋巴结转移的NSCLC患者血清NSE、SCCA水平高于未发生患者,差异有统计学意义(P<0.05);经点二列相关性分析,NSCLC患者血清NSE、SCCA水平与淋巴结转移呈正相关(r>0(P<0.05));绘制受试者工作特征(ROC)曲线,结果显示,血清NSE、SCCA水平及联合评估NSCLC患者淋巴结转移的AUC均>0.7,评估价值较好。结论:血清NSE、SCCA水平与NSCLC患者淋巴结转移呈正相关,且血清NSE、SCCA水平对NSCLC患者淋巴结转移具有一定的评估价值。
Objective:To count the levels of serum neuron-specific enolase(NSE)and squamous cell carcinoma antigen(SCCA)in patients with non-small cell lung cancer(NSCLC),and to analyze the relationship between the levels of serum NSE and SCCA and lymph node metastasis in patients with NSCLC.Methods:110 patients with NSCLC in a hospital from June 2020 to June 2021 were selected as the research subjects.The levels of serum NSE and SCCA in patients with NSCLC were measured,the incidence of lymph node metastasis in patients with NSCLC was counted,and the relationship between the levels of serum NSE and SCCA and lymph node metastasis was analyzed.Results:Acupuncture biopsy confirmed that 41 of 110 patients with NSCLC had lymph node metastasis,with an incidence of 37.27%.The levels of serum NSE and SCCA in NSCLC patients with lymph node metastasis were higher than those in patients without lymph node metastasis,the difference was statistically significant(P<0.05).The point biserial correlation analysis showed that the levels of serum NSE and SCCA in patients with NSCLC were positively correlated with lymph node metastasis(r>0,P<0.05).By drawing the receiver operating characteristic(ROC)curve,the results showed that AUC values of serum NSE,SCCA levels and in combination in the evaluation of lymph node metastasis in patients with NSCLC were>0.7,with good evaluation value.Conclusion:The levels of serum NSE and SCCA are positively correlated with lymph node metastasis in patients with NSCLC,and the levels of serum NSE and SCCA have certain evaluation value for lymph node metastasis in patients with NSCLC.
作者
董颖
Dong Ying(Department of Medical Laboratory,Xiuwu County People's Hospital,Jiaozuo 454350)
出处
《数理医药学杂志》
CAS
2022年第7期1016-1019,共4页
Journal of Mathematical Medicine
