摘要
背景:石墨烯及其衍生物因其优越的性能获得学者们的广泛关注,其性质和应用已成为研究热点。目前研究主要涉及抗菌性能、组织工程支架、诱导牙源性干细胞再生及成骨分化等方面,这与牙周病的治疗目标不谋而合。目的:综述石墨烯及其衍生物在牙周病治疗领域中的研究进展,证实石墨烯及其衍生物类材料在牙周病治疗方面具有良好的应用前景。方法:应用计算机检索CNKI、万方数据库、ScienceDirect、PubMed、Medline数据库2000年1月至2022年4月发表的相关文献,检索词为“石墨烯,牙周病,生物相容性,抗菌机制,牙源性干细胞,引导牙周组织再生”“graphene,periodontal disease,biocompatibility,antibacterial mechanism,odontogenic stem cells,guided tissue regeneration”。通过阅读文题和摘要进行初步筛选,排除与文章主题不相关的文献,根据纳入标准和排除标准,最终纳入67篇文献进行结果分析。结果与结论:①石墨烯及其衍生物通过自身抗菌及载药抗菌,对牙周病常见致病菌有良好的抑制作用;②石墨烯及其衍生物可作为组织工程支架搭载细胞、增加黏附点促进细胞迁移、增殖,并可以促进牙源性干细胞的生长及成骨分化,有利于牙周支持组织的重建。
BACKGROUND:Grophene-family nanomaterials have received extensive attention from scholars due to their superior properties,and their properties and applications have become research hotspots.The current research mainly involves antibacterial properties,tissue engineering scaffolds,induction of odontogenic stem cell regeneration and osteogenic differentiation,which coincides with the treatment goals of periodontal disease.OBJECTIVE:To review the research progress of grophene-family nanomaterials in the field of periodontal disease treatment,and to confirm that grophene-family nanomaterials have good application prospects in the prevention and treatment of periodontal disease.METHODS:The relevant articles published from January 2000 to April 2022 in CNKI,Wanfang Database,ScienceDirect,PubMed,and Medline databases were searched by computer.The search terms were“grapheme,periodontal disease,biocompatibility,antibacterial mechanism,odontogenic stem cells,guided tissue regeneration”.By reading the title and abstract of the preliminary screening,the literature that was not related to the theme of the article was excluded.According to the inclusion and exclusion criteria,67 articles were finally included for the result analysis.RESULTS AND CONCLUSION:(1)Grophene-family nanomaterials have a good inhibitory effect on common pathogenic bacteria of periodontal disease through their own antibacterial and drug-loaded antibacterial effects.(2)Grophene-family nanomaterials can be used as tissue engineering scaffolds to carry cells and increase adhesion.It can promote cell migration and proliferation,and the growth and osteogenic differentiation of dental stem cells,which is conducive to the reconstruction of periodontal support tissues.
作者
任文燕
刘雪
王一宇
Ren Wenyan;Liu Xue;Wang Yiyu(School of Stomatology,Jining Medical University,Jining 272067,Shandong Province,China)
出处
《中国组织工程研究》
CAS
北大核心
2023年第12期1954-1960,共7页
Chinese Journal of Tissue Engineering Research
基金
济宁市重点研发计划项目:口腔黏膜敷药器的研发和推广(2021YXNS032),项目负责人:刘雪
济宁医学院大学生创新训练计划项目(cx2021131),项目负责人:任文燕。
关键词
石墨烯
牙周病
生物相容性
抗菌机制
牙源性干细胞
综述
graphene
periodontal disease
biocompatibility
antibacterial mechanism
odontogenic stem cell
review
