摘要
目的对武汉地区无偿献血人群进行戊型肝炎病毒核酸筛查,调查无偿献血者戊型肝炎病毒现症感染情况,为完善血液筛查策略提供依据。方法对2020年11~12月武汉地区经常规筛查合格的献血者血液标本进行HEV核酸检测,对筛查结果进行分析,并对检测结果呈重复反应性的献血者进行追踪随访以明确其感染状态。结果2020年11~12月共收集17409份献血者标本,对其中经常规筛查合格的17322份标本进行了HEV核酸检测,检出HEV RNA反应性1例,追踪随访结果显示该献血者献血时处于HEV血清学窗口期。本地区无偿献血人群的戊型肝炎病毒现症感染率为0.058‰(1/17322)。结论武汉地区无偿献血人群的戊型肝炎病毒现症感染率相对较低,通过对献血者采取选择性筛查的策略,可进一步降低输血感染戊肝的潜在风险。
Objective To investigate the situation of hepatitis E virus(HEV)infection among voluntary blood donors in Wuhan area and provide evidences for enhancing blood screening strategies.Methods HEV nucleic acid detection(NAT)was performed on blood samples from eligible blood donors in Wuhan from November to December 2020.The testing results were analyzed,and the blood donors with repeated reactive results were followed up to clarify the status of infection.Results Routine screening was performed on 17409 blood samples from November to December 2020.A total of 17322 blood samples of eligible blood donors were tested for HEV NAT,and one case of HEV RNA reactivity was detected.The results from the follow-ups showed that the blood donor should be in the window period of HEV seroconversion.The current HEV infection rate of voluntary blood donors in Wuhan arewas 0.058‰(1/17322),which was lower than other domestic areas.Conclusion The current HEV infection rate of voluntary blood donors was at a relatively low prevalence level in Wuhan area.Selective blood screening strategies can be taken to further reduce potential risk of blood transfusion infection with hepatitis E virus.
作者
赵磊
罗燕平
许婷婷
余琴
李瑜
张丽洁
付珊
贾沙沙
ZHAO Lei;LUO Yanping;XU Tingting;YU Qing;LI Yu;ZHANG Lijie;FU Shan;JIA Shasha(Wuhan Blood Center,Wuhan 430030,Chinn)
出处
《中国输血杂志》
CAS
2022年第6期644-647,共4页
Chinese Journal of Blood Transfusion
基金
中国医学装备协会输血医学装备技术专业委员会血液筛查技术科研项目(XS2020-3-2)
湖北省卫生健康委2021~2022年度面上项目(WJ2021M023)
武汉中青年医学骨干人才培养工程(2017)。
关键词
戊型肝炎病毒
核酸检测
献血者
血液筛查
窗口期
hepatitis E virus
nucleic acid testing
blood donor
blood screening
window period
