摘要
目的探讨选择性半导体激光前列腺汽化术对前列腺增生患者膀胱功能、生活质量及CD68、碱性成纤维细胞生长因子(bFGF)水平的影响。方法选取2018年5月至2020年5月我院收治的120例前列腺增生患者为研究对象,根据随机数字表法将其分为对照组与观察组,各60例。对照组采用传统经尿道前列腺电切术治疗,观察组采用选择性半导体激光前列腺汽化术治疗。比较两组患者的临床疗效。结果观察组的手术时间、膀胱冲洗时间、导尿管留置时间均短于对照组,术中出血量少于对照组(P<0.05)。治疗后,观察组的残余尿量(RUV)少于对照组,最大尿流率(Qmax)、最大尿道关闭压(MUCP)、膀胱顺应性(BC)高于对照组(P<0.05)。治疗后,观察组的血清CD68及bFGF、前列腺特异性抗原(PSA)水平低于对照组,钠(Na)水平高于对照组(P<0.05)。观察组术后并发症总发生率为5.00%,低于对照组的23.33%(P<0.05)。治疗后,观察组的国际勃起功能指数-5(IIEF-5)、生活质量测定量表(QOL)评分高于对照组,国际前列腺症状评分(IPSS)低于对照组(P<0.05)。结论选择性半导体激光前列腺汽化术可有效提升前列腺增生患者的整体疗效,改善患者的膀胱功能,调节CD68、bFGF水平,还能降低术后并发症发生率,从而提高患者的生活质量,值得临床推广应用。
Objective To explore the effects of selective semiconductor laser vaporization of prostate on bladder function,quality of life,CD68 and basic fibroblast growth factor(bFGF)level in patients with prostatic hyperplasia.Methods A total of 120 patients with prostatic hyperplasia admitted in our hospital from May 2018 to May 2020 were selected as the research objects,and the patients were divided into control group and observation group according to random number table method,with 60 cases in each group.The control group was treated with traditional transurethral resection of prostate,and the observation group was treated with selective semiconductor laser vaporization of prostate.The clinical efficacy of the two groups was compared.Results The operation time,bladder washing time and catheter indwelling time in the observation group were shorter than those in the control group,and the amount of intraoperative bleeding was less than that in the control group(P<0.05).After treatment,the residual urine volume(RUV)of the observation group was less than that of the control group,and the maximum urine flow rate(Qmax),maximum urethral closure pressure(MUCP)and bladder compliance(BC)were higher than those of the control group(P<0.05).After treatment,the serum CD68 and levels of bFGF and prostate specific antigen(PSA)in the observation group were lower than those in the control group,and the level of Na was higher than that in the control group(P<0.05).The total incidence of postoperative complications in the observation group was 5.00%,which was lower than 23.33%in the control group(P<0.05).After treatment,international index of erectile function-5(IIEF-5)and quality of life(QOL)scores of the observation group were higher than those of the control group,while international prostate symptom score(IPSS)was lower than that of the control group(P<0.05).Conclusion Selective semiconductor laser vaporization of prostate can effectively promote the overall curative effect of patients with prostatic hyperplasia,improve the bladder function,adjust the CD68 and level of bFGF,and reduce the incidence of postoperative complications,thereby improving the quality of life of the patients,which is worthy of clinical promotion and application.
作者
康波
季金涛
张武合
李永红
KANG Bo;JI Jintao;ZHANG Wuhe;LI Yonghong(Hospital of Air Force,Xi'an 710054,China)
出处
《临床医学研究与实践》
2022年第21期62-66,共5页
Clinical Research and Practice
关键词
选择性半导体激光前列腺汽化术
经尿道前列腺电切术
前列腺增生
膀胱功能
selective semiconductor laser vaporization of prostate
transurethral resection of clinical prostate
prostatic hyperplasia
bladder function
