摘要
本研究探讨磁共振扩散加权成像(DWI)表观扩散系数(ADC)与直肠癌类型、病理分化程度的相关性及临床预测价值。采取回顾性研究方法,选取直肠癌患者105例(观察组),同时选取直肠良性病变患者50例作为对照组,比较两组病灶ADC值差异,同时分析不同临床病理、预后直肠癌患者病灶ADC值差异。结果显示:观察组病灶ADC值为明显低于对照组(P<0.05);低分化、Dukes分期C~D期、有淋巴结外肿瘤种植、Ki-67≥14%患者ADC值明显低于中高分化、A~B期、无淋巴结外肿瘤种植和Ki-67<14%患者(P<0.05);直肠癌病灶ADC值与Ki-67指数呈负相关(r=-0.578,P<0.05);ADC值预测低分化、Dukes分期C~D期的ROC曲线下面积分别为0.827和0.770(P<0.05);ADC值预测有淋巴结外肿瘤种植的ROC曲线下面积为0.620(P<0.05);死亡患者病灶ADC值低于存活患者(P<0.05);ADC值预测患者预后的ROC曲线下面积为0.602(P>0.05)。直肠癌病灶ADC值在预测分化程度、Dukes分期方面有一定应用价值。
This study explored the correlation and clinical predictive value of the apparent diffusion coefficient(ADC)value of diffusion weighted imaging(DWI)with the type and degree of pathological differentiation of rectal cancer.Using a retrospective study,105 patients with rectal cancer were selected as observation group,and 50 patients with benign rectal lesions were selected as the control group.Compared the difference of ADC value between the two groups,and then analyzed the differences of ADC values in rectal cancer patients with different clinicopathological and prognosis.The results showed that,the ADC value of lesions in the observation group was significantly lower than that in the control group(P<0.05).The ADC values of patients with low differentiation,Dukes stage C-D,extranodal tumor implantation and Ki-67≥14%were significantly lower than that of patients with medium and high differentiation,stage A-B,no extranodal tumor implantation and Ki-67<14%(P<0.05).The ADC value of rectal cancer lesions was negatively correlated with Ki-67(r=-0.578,P<0.05).ADC value predicted the areas under ROC curve of poorly differentiated and Dukes stages C-D were 0.827 and 0.770,respectively(P<0.05).ADC value predicted the area under ROC curve with extranodal tumor implantation was 0.620(P>0.05).The ADC value of lesions in deceased patients was lower than that of surviving patients(P<0.05).The area under ROC curve of ADC value predicting prognosis was 0.602(P>0.05).The ADC value of rectal cancer has certain application value in predicting the degree of differentiation and Dukes stage.
作者
陈倩
张艳楠
刘杰
黄硕
CHEN Qian;ZHANG Yannan;LIU Jie;HUANG Shuo(Department of Radiology,Wuhan Fourth Hospital,Wuhan 430000,Hubei,P.R.China;Department of Radiology,Wuhan Union Medical College Hospital,Wuhan 430000,Hubei,P.R.China)
出处
《影像科学与光化学》
CAS
北大核心
2022年第4期789-793,共5页
Imaging Science and Photochemistry
关键词
磁共振扩散加权成像
表观扩散系数
直肠癌
临床病理特征
预测价值
magnetic resonance diffusion weighted imaging
apparent diffusion coefficient
rectal cancer
clinicopathological features
predictive value
