摘要
本次研究目的是探讨CT灌注成像(CTP)联合微小核糖核酸-195(miR-195)在急性脑梗死诊断及预后判断中的价值。选取158例急性脑梗死患者作为观察组,100例健康体检者作为对照组,采用PCR法检测两组血清miR-195水平,比较观察组不同患者梗死区脑血流量(CBF)、脑血容量(CBV)、对比剂平均通过时间(MTT)、达峰时间(TTP)的差异,同时分析各参数预测预后不良的价值。观察组血清miR-195水平明显高于对照组(P<0.05);NIHSS评分≥5分、预后不良患者梗死区CBF、CBV、MTT、TTP明显低于NIHSS评分<5分、预后良好患者(P<0.05),而TTP、血清miR-195相对表达量明显高于NIHSS评分<5分、预后良好患者(P<0.05)。CBF、CBV、MTT与NIHSS评分呈负相关(P<0.05),TTP、血清miR-195相对表达量与NIHSS评分呈正相关(P<0.05)。CBF、CBV、MTT、TTP、miR-195及联合预测急性脑梗死预后不良的ROC曲线下面积分别为0.685、0.867、0.630、0.736、0.669和0.936(P<0.05)。CBF、CBV、MTT、TTP联合miR-195可有效预测急性脑梗死患者预后。
The purpose of this study was to explore the value of CT perfusion imaging(CTP)combined with microRNA-195(miR-195)in the diagnosis and prognosis of acute cerebral infarction.158 patients with acute cerebral infarction(the observation group)and 100 healthy people were selected(the control group).The serum miR-195 levels of patients in the two groups were detected by PCR,and the differences of cerebral blood flow(CBF),cerebral blood volume(CBV),mean transit time(MTT)and time to peak(TTP)in the infarct area of different patients in the observation group were compared,at the same time the value of each parameter in predicting poor prognosis was analyzed.The level of serum miR-195 in the observation group was significantly higher than that in the control group(P<0.05).The CBF,CBV,MTT and TTP in the infarct area of patients with NIHSS score≥5 and poor prognosis were significantly lower than those with NIHSS score<5 and good prognosis(P<0.05),while TTP and serum miR-195 relative expression was significantly higher than those with NIHSS score<5 and good prognosis(P<0.05).CBF,CBV and MTT were negatively correlated with NIHSS score(P<0.05),and the relative expression of TTP and serum miR-195 were positively correlated with NIHSS score(P<0.05).The areas under the ROC curve of CBF,CBV,MTT,TTP,miR-195 and combined prediction of poor prognosis of acute cerebral infarction were 0.685,0.867,0.630,0.736,0.669 and 0.936,respectively(P<0.05).CBF,CBV,MTT,TTP combined with miR-195 can predict the prognosis of patients with acute cerebral infarction effectively.
作者
韩龙
张海莲
马琼
HAN Long;ZHANG Hailian;MA Qiong(Department of Radiology,Qinghai University Affiliated Hospital,Qinghai 810007,Xining,P.R.China;Department of Imaging,The Fifth People’s Hospital of Qinghai Province,Qinghai 810007,Xining,P.R.China)
出处
《影像科学与光化学》
CAS
北大核心
2022年第4期927-931,共5页
Imaging Science and Photochemistry
