摘要
目的分析干扰素γ(interferon-γ,IFN-γ)、白细胞介素6(interleukin-6,IL-6)、白细胞介素4(interleukin-4,IL-4)在含硼替佐米方案治疗致多发性骨髓瘤(multiple myeloma,MM)感染带状疱疹患者中的表达及意义。方法选取含硼替佐米方案致MM感染带状疱疹患者60例作为MM感染带状疱疹组,单纯MM患者60例作为MM组,另选取健康体检者60例为健康组。通过酶联免疫吸附测定(enzyme-linked immunosorbent assay,ELISA)法检测3组IFN-γ、IL-6、IL-4水平。分析IFN-γ、IL-6、IL-4在MM感染带状疱疹中的表达与MM感染带状疱疹严重程度的关系。结果MM组、MM感染带状疱疹组IFN-γ水平低于健康组,IL-6、IL-4水平高于健康组,MM感染带状疱疹组IFN-γ水平较低于MM组,IL-6、IL-4水平高于MM组,差异有统计学意义(P<0.05)。重度、中度感染带状疱疹患者IFN-γ水平低于轻度感染带状疱疹患者,IL-6、IL-4水平高于轻度感染带状疱疹患者;MM重度感染带状疱疹患者IFN-γ水平低于中度感染带状疱疹患者,IL-6、IL-4水平高于中度感染带状疱疹患者,差异有统计学意义(P<0.05)。相关性分析显示,IFN-γ与MM感染带状疱疹严重程度呈负相关,IL-6、IL-4与MM感染带状疱疹严重程度呈正相关(P<0.05)。Logistic回归模型分析结果显示,IFN-γ、IL-6、IL-4是MM感染带状疱疹的危险因素。IFN-γ与IL-6呈负相关,IFN-γ与IL-4呈负相关,IL-6与IL-4呈正相关(P<0.05)。三项联合对MM感染带状疱疹的诊断价值高于与IFN-γ、IL-6、IL-4单项诊断(P<0.05)。结论IFN-γ表达降低、IL-6、IL-4表达升高可加重MM感染带状疱疹患者的免疫功能异常及炎症反应,临床可根据IFN-γ、IL-6、IL-4水平变化对MM感染带状疱疹病情的严重程度进行判断。
Objective To analyze expression and significance of interferon-γ(IFN-γ),interleukin-6(IL-6)and interleukin-4(IL-4)in patients with multiple myeloma(MM)complicated with herpes zoster infection caused by bortezomib-containing regimen.Methods In total,60 patients with MM complicated with herpes zoster infection caused by bortezomib-containing regimen were selected as MM complicated with herpes zoster infection group,and 60 patients with simple MM were selected as MM group,and 60 healthy physical examinees were selected as healthy group.The levels of IFN-γ,IL-6 and IL-4 of three groups were detected by enzyme linked immunosorbent assay(ELISA).The relationship between the expression of IFN-γ,IL-6 and IL-4 in MM patients with herpes zoster infection and the severity of MM complicated with herpes zoster infection was analyzed.Results The levels of IFN-γin MM group and MM complicated with herpes zoster infection group were lower than those in healthy group,while the levels of IL-6 and IL-4 were higher than those in healthy group;the level of IFN-γin MM complicated with herpes zoster infection group was lower than that in MM group,while the levels of IL-6 and IL-4 were higher than those in MM group,suggesting significant differences(P<0.05).The level of IFN-γin patients with severe and moderate herpes zoster was lower than that in patients with mild herpes zoster infection,while the levels of IL-6 and IL-4 were higher than those in patients with mild herpes zoster infection;The level of IFN-γin patients with severe herpes zoster was lower than that in patients with moderate herpes zoster,while the levels of IL-6 and IL-4 were higher than those in patients with moderate herpes zoster,and the differences were statistically significant(P<0.05).Correlation analysis showed that IFN-γwas negatively correlated with the severity of MM complicated with herpes zoste rinfection,while IL-6 and IL-4 were positively correlated with the severity of MM complicated with herpes zoster infection(P<0.05).Logistic regression model analysis showed that IFN-γ,IL-6 and IL-4 were the risk factors of MM complicated with herpes zoster infection.IFN-γwas negatively correlated with IL-6 and positively correlated with IL-4,and IL-6 was positively correlated with IL-4(P<0.05).The diagnostic value of the three in combination in MM complicated with herpes zoster infection was higher than that of IFN-γ,IL-6 and IL-4 alone(P<0.05).Conclusion The decreased expression of IFN-γand increased expression of IL-6 and IL-4 can aggravate the abnormal immune function and inflammatory response of MM patients with herpes zoster infection.In clinical practice,changes in the levels of IFN-γ,IL-6 and IL-4 can be used to judge the severity of MM complicated with herpes zoster infection.
作者
彭翔宇
侯健
顾佳鑫
刘蕾
PENG Xiang-yu;HOU Jian;GU Jia-xin;LIU Lei(Department of Clinical Laboratory, Kailuan General Hospital of Tangshan City, Hebei Province, Tangshan 063000, China)
出处
《河北医科大学学报》
CAS
2022年第7期827-831,共5页
Journal of Hebei Medical University
基金
河北省医学科学研究课题计划(20191644)。
