摘要
螺环化合物是一类重要的有机化合物,具有较强的刚性和结构相对稳定性,此外还具有广泛的生物活性,如抑菌、杀虫、镇痛消炎以及抗肿瘤等,在不对称催化、材料,尤其是医药研究等领域具有广泛应用。综述了螺环化合物的合成方法,并对其在药物研究领域的应用进展进行了评述。
Spirocyclic compounds are very important organic compounds with strong rigidity and relatively stable structure.They have a wide range of biological activities, such as bacteriostasis, insecticidal, analgesic and anti-inflammatory, anti-tumor and so on.They have important applications in asymmetric catalysis, materials, especially medicine research and other fields.In this paper, the synthetic methods of spirocyclic compounds were reviewed, and their application in the field of drug research was also reviewed.
作者
高艳蓉
仝红娟
赵梅梅
杜漠
唐文强
GAO Yan-rong;TONG Hong-juan;ZHAO Mei-mei;DU Mo;TANG Wen-qiang(School of Pharmacy,Shaanxi Institute of International Trade&Commerce,Xianyang 712046,China;Collaborative Innovation Center of Green Manufacturing Technology for Traditional Chinese Medicine in Shaanxi Province,Xianyang 712046,China)
出处
《精细与专用化学品》
CAS
2022年第6期37-41,共5页
Fine and Specialty Chemicals
基金
陕西国际商贸学院“中药药效物质研究”创新团队资助项目(SSY18TD02)
咸阳市分子影像与药物合成重点实验室项目(2021QXNL-PT-0008)。
关键词
螺环化合物
合成方法
药物研究
应用进展
spirocompound
synthetic method
drug research
application progress
