摘要
目的:探讨乙型病毒性肝炎失代偿性肝硬化患者应用恩替卡韦的疗效及甲状腺功能的变化情况。方法:选取2020年4月-2021年4月英山县人民医院收治的乙型病毒性肝炎失代偿性肝硬化患者120例进行本次研究,将其采用随机数字表法分为对照组(60例)和观察组(60例)。对照组给予阿德福韦酯+常规治疗,观察组给予恩替卡韦+常规治疗,两组患者均连续治疗20周。比较两组治疗后临床效果,治疗前后肝功能变化、甲状腺功能及治疗期间安全性。结果:治疗后观察组的临床总有效率(78.33%)高于对照组(58.33%)(P<0.05);两组患者治疗后血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(TBIL)、促甲状腺素(TSH)水平及Child-Pugh评分较治疗前相比均降低,且观察组比对照组低(P<0.05);两组患者治疗后血清三碘甲状腺原氨酸(T_(3))、甲状腺素(T_(4))、游离三碘甲状腺原氨酸(FT_(3))、游离甲状腺素(FT_(4))水平较治疗前相比均升高,且观察组比对照组高(P<0.05);两组患者在治疗期间不良反应的总发生率经对比差异无统计学意义(P>0.05)。结论:乙型病毒性肝炎失代偿性肝硬化患者应用恩替卡韦治疗可有效降低HBV对肝细胞的损伤,保护患者的甲状腺及肝功能,治疗效果显著。
Objective:To explore the effect of Entecavir treatment and the changes of thyroid function in patients with decompensated liver cirrhosis due to hepatitis B.Method:A total of 120 decompensated cirrhotic patients with hepatitis B virus from April 2020 to April 2021 in Yingshan County People’s Hospital,and were divided into control group(n=60)and observation group(n=60)according to the random number table method.The control group was given Adefovir Dipivoxil+conventional treatment,the observation group was given Entecavir+conventional treatment,and patients in both groups were treated continuously for 20 weeks.The clinical outcomes,liver function changes before and after treatment,thyroid function,and safety during treatment were compared between the two groups.Result:The clinical overall response rate was higher in the observation group after treatment(78.33%)than that in the control group(58.33%)(P<0.05).Serum ALT,AST,TBIL,TSH levels and Child-Pugh scores were reduced after treatment in both groups compared with before treatment,and which were lower in the observation group than those in the control group(P<0.05).Serum T_(3),T_(4),FT_(3),and FT_(4)levels increased after treatment in both groups compared with before treatment,which were higher in the observation group than those in the control group(P<0.05).The overall incidence of adverse effects during treatment was compared between the two groups,and there was no significant difference(P>0.05).Conclusion:Entecavir treatment in patients with hepatitis B decompensated liver cirrhosis can effectively reduce the damage of HBV to liver cells,and protect the thyroid and liver function of the patients,which has therapeutic effect.
作者
徐亚柳
夏旺存
冯立荣
XU Yaliu;XIA Wangcun;FENG Lirong(Yingshan County People’s Hospital,Yingshan 438700,China;不详)
出处
《中外医学研究》
2022年第17期132-135,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
