摘要
目的:探究清创术联合抗骨髓炎片对慢性骨髓炎(COM)患者的影响。方法:选择2019年7月-2020年6月在德阳市人民医院治疗的94例COM患者,将上述病例按随机数字表法分为观察组和对照组各47例,对照组采用清创术治疗,并于术后给予抗生素治疗,观察组采用清创术联合抗骨髓片治疗,比较两组临床疗效、炎症因子指标、核转录因子(NF-κB)、住院时间及病情复发情况。结果:观察组总有效率为85.11%,高于对照组的65.96%(P<0.05)。治疗后3个月,观察组CRP、IL-6、NF-κB表达均低于对照组,且IL-4表达高于对照组(P<0.05)。观察组住院时间、骨吸收时间、骨缺损愈合时间均短于对照组(P<0.05)。观察组随访6、12个月复发率分别为2.50%、5.00%,均分别低于对照组的22.58%、35.48%(P<0.05)。结论:对COM患者在清创术后结合抗骨髓炎片治疗能进一步提高治疗效果,有助于控制炎症反应,抑制NF-κB表达,缩短康复时间,减少病情复发。
Objective:To explore the effect of debridement combined with Kang Gusuiyan Tablets on patients with chronic osteomyelitis(COM).Method:A total of 94 patients with COM treated in Deyang People’s Hospital from July 2019 to June 2020 were selected.The above cases were divided into observation group and control group by random number table method,47 cases in each group.The control group was treated with debridement and given antibiotic treatment after operation.The observation group was treated with debridement combined with Kang Gusuiyan Tablets.The clinical efficacy,inflammatory factor index and nuclear factor(NF-κB),hospitalization time and recurrence of the two groups were compared.Result:The total effective rate of the observation group was 85.11%,which was higher than 65.96%of the control group(P<0.05).Three months after treatment,the expression of CRP,IL-6 and NF-κB in the observation group were lower than those of the control group,and the expression of IL-4 was higher than that of the control group(P<0.05).The hospitalization time,bone resorption time and bone defect healing time in the observation group were shorter than those in the control group(P<0.05).The recurrence rates of the observation group at 6 and 12 months of follow-up were 2.50%and 5.00%respectively,which were lower than 22.58%and 35.48%of the control group(P<0.05).Conclusion:The treatment of COM patients after debridement combined with Kang Gusuiyan Tablets can further improve the therapeutic effect,help to control the inflammatory response and inhibit NF-κB expression,shorten the rehabilitation time and reduce the recurrence of the disease.
作者
欧乙利
OU Yili(Deyang People’s Hospital,Deyang 618000,China)
出处
《中外医学研究》
2022年第17期142-145,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
清创术
抗骨髓炎片
慢性骨髓炎
临床疗效
Debridement
Kang Gusuiyan Tablets
Chronic osteomyelitis
Clinical efficacy
