摘要
目的分析孕中期孕妇血清铁蛋白(SF)水平与甲状腺过氧化物酶抗体(TPO-Ab)、甲状腺球蛋白抗体(TG-Ab)的关系。方法以2016年12月至2017年7月该院产科门诊入选的1592例孕中期孕妇为研究对象,以SF 12μg/L为截点将研究对象分为铁缺乏组和铁正常组,分析两组间甲状腺功能指标及甲状腺自身抗体的差异,探讨孕中期孕妇SF水平与甲状腺自身抗体的关系。结果铁缺乏组游离甲状腺素水平明显低于铁正常组,差异有统计学意义(P<0.05),而两组间促甲状腺激素水平、检出TPO-Ab或TG-Ab阳性率及亚临床甲状腺功能减退症比例比较,差异均无统计学意义(P>0.05)。Logistic回归分析证实铁缺乏症为孕妇单纯TG-Ab水平异常升高的危险因素[OR=2.840,95%CI(1.385~5.825),P<0.05],不是孕妇TPO-Ab水平异常升高的危险因素[OR=0.712,95%CI(0.296~1.711),P>0.05]。结论孕中期铁缺乏症是TG-Ab水平异常升高的危险因素。
Objective To analyze the relationships between serum ferritin(SF)level and thyroid peroxidase antibody(TPO-Ab),thyroglobulin antibody(TG-Ab)in pregnant women during the second trimester of pregnancy.Methods A total of 1592 pregnant women enrolled in the Department of Obstetrics in the Fifth People′s Hospital of Shanghai Fudan University from December 2016 to July 2017 were selected as the study subjects.The subjects were divided into iron deficiency group and iron normal group using SF 12μg/L as the cut-off point.The differences on thyroid function indexes and thyroid autoantibodies between the two groups were analyzed,and the relationships between SF level and thyroid autoantibodies in pregnant women in the second trimester were discussed.Results The level of free thyroid hormone in iron deficiency group was significantly lower than that in iron normal group,and the difference was statistically significant(P<0.05),while there was no significant difference on the thyrotropin level,the positive rates of TPO-Ab or TG-Ab and the incidence of subclinical hypothyroidism between the two groups(P>0.05).Logistic regression analysis confirmed that iron deficiency was a risk factor for abnormal increase of TG-Ab level alone in pregnant women[OR=2.840,95%CI(1.385—5.825),P<0.05],but not for abnormal increase of TPO-Ab level in pregnant women[OR=0.712,95%CI(0.296-1.711),P>0.05].Conclusion Iron deficiency in the second trimester is a risk factor for abnormally elevated TG-Ab level.
作者
柯文才
陈灶萍
查兵兵
李晓莹
黄新梅
杨倩
盛励
刘军
KE Wencai;CHEN Zaoping;ZHA Bingbing;LI Xiaoying;HUANG Xinmei;YANG Qian;SHENG Li;LIU Jun(Department of Clinical Laboratory,the Fifth People′s Hospital of Shanghai Fudan University,Shanghai 200240,China;Department of Endocrinology,the Fifth People′s Hospital of Shanghai Fudan University,Shanghai 200240,China)
出处
《检验医学与临床》
CAS
2022年第14期1930-1933,1939,共5页
Laboratory Medicine and Clinic
基金
上海市闵行区科委自然科学基金项目(2019MHZ019)。
