摘要
目的:探讨肝动脉化疗栓塞(TACE)术后Ⅲa期原发性肝细胞癌(HCC)患者无进展生存的有关影响因素。方法:收集60例行TACE术的Ⅲa期HCC患者的临床资料,采用COX风险回归模型对13项临床因素进行单因素分析;采用多因素回归分析筛选出患者无进展生存的独立影响因素。结果:单因素分析结果显示,实体瘤状态、PVTT分型、有无门静脉治疗、AFP表达水平为患者术后无进展生存的影响因素(P<0.05)。多因素分析显示门静脉治疗是患者术后无进展生存的独立保护因素(P=0.030);肿瘤部分缓解、AFP水平>400μg/L是患者术后无进展生存的独立危险因素(P<0.05)。结论:实体肿瘤状态、AFP水平、有无门静脉治疗可能是Ⅲa期HCC患者TACE术后预后的主要影响因素。
Objective:To analyze the related elements affecting the progression-free survival of patients with primary hepatocellular carcinoma stageⅢa after transarterial chemoembolization(TACE)treatment.Methods:A retrospective study of the clinical data of 60 patients with stageⅢa liver cancer who underwent TACE treatment.Results:Univariate analysis displayed the evaluation of solid tumors,PVTT classification,the presence or absence of portal vein tumor thrombus treatment,and serum AFP levels were significantly related to the prognosis of patients(P<0.05);multivariate analysis displayed portal vein treatment was substantive benefit elements for progression-free survival in patients with liver cancer stage IIIa;partial tumor remission and AFP>400μg/L are substantive danger elements for patient prognosis.Conclusion:The evaluation of solid tumors,the level of AFP,and the presence or absence of treatment for portal vein tumor thrombi may be the relational elements affecting the prognosis of patients with stageⅢa hepatocellular carcinoma after TACE.
作者
陈晓琦
张鑫
张笑天
赵云霞
冉小柯
范甜雨
陈欣菊
CHEN Xiao-qi;ZHANG Xin;ZHANG Xiao-tian;CHEN Xin-ju(Department of Gastroenterology,the First Affiliated Hospital of Henan University of Traditional Chinese Medicine(Zhengzhou,450000),China)
出处
《中西医结合肝病杂志》
CAS
2022年第7期591-594,共4页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
基金
国家艾滋病和病毒性肝炎等重大传染病防治项目(No.2018ZX10303502)
河南省特色骨干学科中医学学科建设重点项目(No.STG-ZYXKY-2020019)
河南省中医管理局科研专项课题(No.2018JDZX110)
河南省中医管理局科研专项课题(No.2017JDZX029)。
关键词
原发性肝癌
肝动脉化疗栓塞术
预后
primary liver cancer
transarterial chemoembolization
prognosis
