摘要
聚类肽(N-聚甘氨酸)材料是一种具有良好的抗生物化学、可降解性和生物相容性的新型高分子生物材料,因其分子结构中酰胺键上的活泼肽键氢原子结构可被完全取代,使得聚类肽的主链分子结构与其中的多重活泼氢键间的相互作用被完全消除,柔顺性变好。因此,聚合物类肽侧链基团可以在很大程度上决定其他类聚合物的主要物理、化学性质,从而其性能的改变可通过改变其侧链结构途径实现。对各种聚第二类肽的化学合成常用方法,如固相法和开环聚合法等进行了综述,详细地介绍了各种聚类肽的物理化学性能,包括聚第一类肽的溶解性、抗菌性和聚第二类肽的化学温敏性、表面性、防污性、生物相容性及自组装等,为聚类肽的进一步开发与应用提供借鉴。
Cluster peptide(N-polyglycine)is a kind of polymer material with good biodegradability and compatibility.Because of the substitution of amide bond active hydrogen in the structure,the multiple hydrogen bond interaction in the main chain structure of polypeptide is eliminated,and its flexibility is improved.The side chain groups of clustering peptides determine the physical and chemical properties of their polymers to a great extent.So the performance of clustering peptides can be changed by changing their side chain structure.In this paper,the synthesis methods of clustering peptides,such as solid phase method and ring opening polymerization,are reviewed.The physicochemical properties of clustering peptides including the solubility,temperature sensitivity,biocompatibility and the properties of antibacterial,surface antifouling and self-assembly of clustering peptides are discussed in details herein,so as to provide reference for the further development and application of clustering peptides.
作者
王筑城
魏玉函
王存国
WANG Zhucheng;WEI Yuhan;WANG Cunguo(Key Laboratory of Rubber-plastics,Ministry of Education,Shandong Province Key Lab.of Rubber-plastics,Qingdao University of Science and Technology,Qingdao 266042,China)
出处
《化工科技》
CAS
2022年第2期83-88,共6页
Science & Technology in Chemical Industry
基金
山东省教育厅项目(SDYJG19089)
山东省潍坊市高层次创新创业人才计划项目(潍办字2013-69)。
关键词
聚类肽
N-聚甘氨酸
环状单体
温敏性
自组装
Cluster peptide
N-polyglycine
Cyclic monomer
Temperature sensitivity
Self-assembly
