摘要
目的研究血清抗缪勒管激素(anti mullerian hormone,AMH)联合基础性激素检测在预测卵巢早衰(premature ovarian failure,POF)方面的临床应用价值。方法以2018年9~12月蚌埠医学院第一附属医院诊治的38例卵巢储备功能下降(diminished ovarian reserve,DOR)女性患者(DOR组)及35例POF女性患者(POF组)作为实验组,对照组为同期健康体检且月经周期正常的28例女性。3组女性的血清基础性激素如血清卵泡刺激素(follicle stimulating hormone,FSH)、黄体生成素(luteinizing hormone,LH)、雌二醇(estradiol,E2)以及AMH的水平均采用罗氏电化学发光全自动免疫分析仪检测,检测结果进行对比分析。结果POF组血清AMH水平于三组内最低,DOR组血清AMH水平呈显著减少,AMH水平最高为对照组,三组差异具备统计学意义(P<0.05)。相较于对照组,POF组LH、FSH表达水平更高,DOR组中也略有升高,各组间差异有统计学意义(P<0.05)。三组中E2水平最低为POF组,相较于正常对照组,差异具备统计学意义(P<0.05),但对照组、DOR组无显著差异。结论POF、DOR患者以及正常健康女性中AMH的表达水平不同,联合检测血清中性激素水平在诊断和预测早期卵巢早衰具有一定的临床应用价值。
Objective To study the clinical application value of serum anti-Mueller hormone(AMH)combined with sex hormone detection in predicting Premature Ovarian Failure(POF).Methods From September 2018 to December 2018,38 women with Diminished Ovarian Reserve(DOR group)and 35 POF female patients(POF group)were treated at the Center for Reproductive Medicine of the Hospital as experimental groups,and the control group was 28 women with normalmenstrual cycles during the same period.Levels of serum-based hormones such as Follicle Stimulating Hormone(FSH),Luteinizing Hormone(LH),Estradiol(E2)and AMH in 3 groups of women were tested using Roche’s electrochemical luminescence fully automatic immunoassay,and the results were compared and analyzed.Results The serum AMH level in POF group was the lowest in three grou ps,the serum AMH level in DOR group was significantly reduced,the AMH level was highest in control group,and the difference in three groups was statistically significant(P<0.05).Compared with the control group,the expression level of LH and FSH in POF group was higher,and the expression level of DOR group was also slightly higher,and the differences between the groups were statistically significant(P<0.05).The lowest level of E2 in the three groups was POF group,and the difference was statistically significant compared to the normal control group(P<0.05),but there was no significant difference between the control group and the DOR group.Conclusion The expression level of AMH is different in POF,DOR patients and normal healthy women,and the combined detection of serum sex hormone level has some clinical application value in diagnosing and predicting early p remature ovarian failure.
作者
张枫
杜丹丽
丁彪
刘雷
王学故
孙军培
ZHANG Feng;DU Danli;DING Biao;LIU Lei;WANG Xuegu;SUN Junpei(Reproduction Medicine Center,The First Affiliated Hospital of Bengbu Medical College,Bengbu,Anhui,233000)
出处
《智慧健康》
2022年第16期71-74,共4页
Smart Healthcare
基金
蚌埠医学院自然科学类项目基金“血清AMH及性激素联合检测在PCOS和POF诊疗中的应用价值研究”(项目编号:BYKY18112)。
