摘要
艾滋病又称获得性免疫缺陷综合征(acquired immunodeficiency syndrome,AIDS)是由人免疫缺陷病毒(human immunodeficiency virus,HIV)引起的一种传染性疾病。目前尚无彻底根除HIV/AIDS的药物,也无相关疫苗研制成功。植物来源的天然产物由于种类丰富、结构多样、毒副作用小等诸多优点,成为艾滋病防治药物或先导化合物不可或缺的一部分。本文简要综述了近5年来具有抗HIV活性的植物来源天然化合物的研究进展,期望通过对其相关研究进展的总结,为抗HIV药物开发提供有潜力的先导化合物。
AIDS,also known as acquired immunodeficiency syndrome,is an infectious disease caused by human immunodeficiency virus.At present,there is no drug that can completely eradicate HIV/AIDS,and no related vaccine has been successfully developed.Plant-derived natural products have become an indispensable part of the prevention and treatment of AIDS or lead compounds due to their rich variety,diverse structures,and lower side effects.This article briefly reviews some plant-derived natural products with anti-HIV activity in recent five years,hopes provides potential lead compounds for the development of anti-HIV drugs by summarizes related research progress.
作者
杨金轩
方浩
陈欢
郑永唐
YANG Jin-xuan;FANG Hao;CHEN Huan;ZHENG Yong-tang(College of Traditional Chinese Medicine,Yunnan University of Chinese Medicine,Kunming 650500,China;Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming 650223,China)
出处
《天然产物研究与开发》
CAS
CSCD
2022年第7期1250-1260,1222,共12页
Natural Product Research and Development
基金
国家自然科学基金(82060670)。
关键词
植物来源
天然产物
人免疫缺陷病毒
抗HIV活性
plant-derived
natural products
human immunodeficiency virus
anti-HIV activity
