摘要
目的:研究4周结合饮食控制的有氧运动对肥胖青年血清炎症因子chemerin的影响,并与经典炎症因子(IL-1β、IL-6和IL-10)进行比较,以明确chemerin是否能成为运动抗炎和健康促进的评估指标。方法:招募111名肥胖青年完成全封闭的4周结合饮食控制的有氧运动,中等强度(靶心率为40%心率储备+安静心率),以快走、游泳、慢跑为主,每周运动6天,每天上下午各2 h,每运动30 min休息5 min;饮食参考个体基础代谢,从3种套餐中选择一种(食物相同,质量不同,每日总能量分别是5023.02 kJ、5860.20 kJ和6697.36 kJ)。试验前后分别检测肥胖程度、糖脂代谢指标、血清chemerin、IL-1β、IL-6和IL-10水平,并比较男性(n=56)和女性(n=55)、减重量大(>10%初始体质量,n=52)和减重量小(初始体质量5%~10%,n=59)受试者间的组间差异,工作特征(ROC)曲线比较chemerin及经典炎症因子作为运动抗炎指标的敏感性和特异性。结果:1)4周结合饮食控制的有氧运动在改善肥胖青年肥胖程度和糖脂代谢的同时,显著降低chemerin、IL-1β和IL-6水平,增加IL-10水平;2)对血清chemerin、IL-6和IL-10的改变无显著性别差异,但肥胖男性的IL-1β降低程度更大;3)减重量大组的糖脂代谢改善程度更大,但仅血清chemerin和IL-1β有组间差异(IL-6和IL-10无组间差异);4)ROC曲线分析显示,chemerin比IL-1β、IL-6和IL-10在反映运动健康促进作用上有更高的敏感性(0.748)和特异性(0.640)。结论:4周结合饮食控制的有氧运动降低肥胖青年的血清chemerin水平,且无性别差异;血清chemerin的降低在评估运动健康促进效应上比经典炎症因子的改变有更优的诊断效能。
Objective:To investigate the effect of 4-week aerobic exercise combined with dieting on the serum inflammatory cytokine chemerin,in obese youth,and to clarify whether chemerin is a better indicator to reflect the anti-inflammation and health promotion of aerobic exercise by comparing with some classic inflammatory factors including IL-1β,IL-6 and IL-10.Methods:One hundred and eleven obese youth were recruited and undertook 4-week aerobic exercise combined with dieting.Aerobic exercise comprised brisk walking,swimming and jogging with moderate intensity(target heart rate:40%heart reserve rate+rest heart rate),they exercised 6 days every week,and they did exercise 2 h in the morning and afternoon respectively every day,they took a rest for 5 min every 30 min.Daily food was choosed 1 from 3 set menus(total energy of 5023.02 kJ,5860.20 kJ and 6697.36 kJ from same food items but different in size)according to individual basal metabolism.Before and after the 4-week intervention,the extent of obesity,glucose and lipid metabolism,serum level of chemerin,IL-1β,IL-6 and IL-10 were measured.The differences between male group(n=56)and female group(n=55),large weight loss group(>10% of basal body weight,n=52)and small weight loss group(5%~10% of basal body weight,n=59)were compared in the levels of chemerin and classic inflammatory factors,and the sensitivity and specificity of the above inflammatory factors in reflecting anti-inflammation of exercise were compared by receiver operating characteristic(ROC)curve.Results:1)Four-week aerobic exercise combined with dieting can not only improve the degree of obesity and glucose and lipid metabolism,but also significantly reduce chemerin and IL-1βAnd IL-6 levels,increasing IL-10 levels;2)the alteration extent of inflammatory factors in obese youth by aerobic exercise combined with dieting existed no significant difference in chemerin,IL-6 and IL-10,but it has greater decrease of IL-1βin obesity males;3)accompanied with better improvements in glucose and lipid metabolism in large weight loss group than small weight loss group,only the serum levels of chemerin and IL-1βbut not IL-6 and IL-10 were observed;4)chemerin showed higher sensitivity(0.748)and specificity(0.640)than classic inflammatory cytokines(IL-1β,IL-6 and IL-10)in evaluating exercise’s health promoting effect by analyzing ROC curve.Conclusions:Serum chemerin was significantly reduced by 4-week aerobic exercise in combination with dieting in obese male and female youth with no gender difference.The decrease of serum chemerin has better diagnostic efficiency in evaluating exercise’s health promoting effect comparing to the alterations of classic inflammatory cytokines.
作者
曲静
林小晶
王业玲
王晓慧
QU Jing;LIN Xiaojing;WANG Yeling;WANG Xiaohui(Shanghai University of Sport,Shanghai 200438,China;Xingyi Normal University for Nationalities,Xingyi 562400,China;Shanghai DianFeng Sports Management Co.,Ltd,Shanghai 200438,China)
出处
《中国体育科技》
CSSCI
北大核心
2022年第7期76-82,共7页
China Sport Science and Technology
基金
国家自然科学基金项目(31872801)
贵州省教育厅青年科技人才成长项目(黔教合KY字〔2017〕366)。
