摘要
目的观察特布他林、孟鲁司特钠联合治疗支气管哮喘(BA)的临床效果及呼吸力学指标变化。方法选取2019年2月—2021年2月在本院治疗的155例BA,根据治疗方案差异分为观察组74例(特布他林雾化吸入联合孟鲁司特钠治疗)和对照组81例(仅予孟鲁司特钠治疗)。比较2组临床疗效,治疗前后呼吸力学指标、咳嗽评分、呼吸困难评分,并观察用药安全性。结果观察组总有效率高于对照组(P<0.05)。治疗后2组呼吸做功(WOB)、气道峰压(PIP)、气道阻力(Raw)水平下降,动态顺应性(Cdyn)水平上升,且观察组WOB、PIP、Raw水平低于对照组,Cdyn水平高于对照组(P<0.05,P<0.01)。2组治疗后咳嗽、呼吸困难评分均下降,且观察组呼吸困难评分降低更明显(P<0.05,P<0.01)。2组不良反应总发生率比较差异无统计学意义(P>0.05)。结论BA患者予特布他林、孟鲁司特钠联合治疗安全性高,疗效理想,可改善患者呼吸力学指标及咳嗽评分。
Objective To observe the clinical effect of Terbutaline and Montelukast sodium in the treatment of bronchial asthma(BA)and changes of respiratory mechanics indexes.Methods A total of 155 BA patients treated in our hospital from February 2019 to February 2021 were selected as the research subjects.According to the difference in treatment plans,they were divided into the observation group(Terbutaline sulfate aerosol inhalation+Montelukast sodium tablets treatment,n=74)and the control group(a Montelukast sodium tablet treatment alone,n=81).The clinical effects,respiratory mechanics index,cough score,and dyspnea score before and after treatment were compared between the two groups,and the safety of medication was observed.Results The total effective rate of the observation group was higher than that of the control group(P<0.05).After treatment,the levels of work of breathing(WOB),peak inspiratory pressure(PIP),and airway resistance(Raw)in the two groups decreased,while the level of Cdyn increased.WOB,PIP and Raw levels in the observation group were lower than those in the control group,while the Cdyn level was higher than that in the control group(P<0.05,P<0.01).The scores of cough and dyspnea in the two groups decreased after treatment,and the dyspnea score of the observation group was lower than that of the control group(P<0.05,P<0.01).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Terbutaline and Montelukast sodium in the treatment of BA has high safety and favorable therapeutic effect,and can improve the respiratory mechanics indexes and cough scores of patients.
作者
张洪琼
闫天凌
钱军
ZHANG Hong-qiong;YAN Tian-ling;QIAN Jun(Department of Central Pharmacy,Panzhihua Hospital of Integrated Traditional Chinese and Western Medicine,Panzhihua,Sichuan 617000,China)
出处
《解放军医药杂志》
CAS
2022年第6期96-99,共4页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
基金
四川省科技计划项目(2019JDR2276)。
关键词
哮喘
特布他林
孟鲁司特钠
临床疗效
气道峰压
气道阻力
Asthma
Terbutaline
Montelukast sodium
Clinical efficacy
Peak inspiratory pressure
Airway resistance
