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布托啡诺在脾切除中对血流动力学及麻醉镇痛效果的影响 被引量:1

Effects of butorphanol on hemodynamics and anesthesia and analgesia in splenectomy
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摘要 探讨布托啡诺在脾切除手术中的应用价值。选取郑州大学附属郑州中心医院实施奇静脉断流术的患者94例,依据随机临床试验原理将其分为试验组(麻醉诱导前给予布托啡诺)和对照组(麻醉诱导前给予生理盐水)各47例,应用丙泊酚完成麻醉诱导,试验组在麻醉诱导前给予布托啡诺,对照组给予等量生理盐水;监测分析两组血流动学指标、麻醉相关指标、手术前后患者疼痛介质水平。T0时刻的平均动脉压(MAP)、心率(HR)、脑电双频指数(BIS)分析,两组差异无统计学意义(P>0.05);试验组在T2、T3时刻BIS值明显低于对照组(P<0.05);两组麻醉诱导时间、手术时间、苏醒时间记录对比,差异无统计学意义(P>0.05);警觉/镇静评分(OAA/S)、丙泊酚总用量在两组之间对比,试验组均低于对照组(P<0.05);术前两组血清P物质(SP)、多巴胺(DA)、去甲肾上腺素(NE)、神经肽(NPY)水平对比差异无统计学意义(P>0.05);术毕5 min血清SP、DA、NE、NPY检测结果,试验组低于对照组(P<0.05);麻醉相关不良反应发生率分别为8.51%、23.40%,试验组低于对照组(P<0.05)。布托啡诺在脾切除手术中的应用能有效提高麻醉效果、减少丙泊酚用量、降低手术引起的疼痛介质水平的波动。
作者 关文川 杨彦军 高金勇 GUAN Wen-chuan;YANG Yan-jun;GAO Jin-yong
出处 《中国现代普通外科进展》 CAS 2022年第7期567-570,共4页 Chinese Journal of Current Advances in General Surgery
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