摘要
扩大切除是目前早期皮肤恶性黑色素瘤的一线治疗方案。为预防肿瘤复发,扩大切除范围经历了从经验切除到基于病理精准检测确定安全距离,从以切净肿瘤为目标到把肿瘤预后作为治疗评判参数的演变。未来恶性黑色素瘤切除范围的确定需将循证医学证据与个体特性相结合以预防不良结局。
Treating malignant melanoma of skin at the early stage depends on wide excision mainly.For the prevention of tumor recurrence,means of acquisition of the safe margin changed from empirical resection to accurate pathological evaluation,and therapeutic target evolved from clearing tumor cells to pursuing the best prognosis.In the future,it would be necessary to combine individualized treatment with evidence-based medicine in the treatment of cutaneous malignant melanoma to prevent adverse outcomes.
作者
彭睿
李航
Peng Rui;Li Hang(Department of Dermatology,Peking University First Hospital,Beijing Key Laboratory of Molecular Diagnosis on Dermatoses,National Clinical Research Center for Skin and Immune Diseases,National Medical Products Administration Key Laboratory for Quality Control and Evaluation of Cosmetics,Beijing 100034,China)
出处
《中华预防医学杂志》
CAS
CSCD
北大核心
2022年第6期871-877,共7页
Chinese Journal of Preventive Medicine
基金
国家重点研发计划项目(2019YFC0840706)
国家自然科学基金面上项目(81572675)。
关键词
黑色素瘤
切除范围
三级预防
Melanoma
Margins of excision
Tertiary prevention
