摘要
目的:观察胃苏颗粒联合四联疗法对幽门螺杆菌(Hp)阳性慢性萎缩性胃炎(CAG)患者血清胃肠激素和胃黏膜氧化酶-2(COX-2)、核转录因子-κB(NF-κB)表达的影响。方法:选取2017年7月~2019年6月期间中国人民解放军总医院第二医学中心消化内科收治的Hp阳性CAG患者120例,根据信封抽签法将患者分为观察组(60例,胃苏颗粒联合四联疗法)、对照组(60例,四联疗法),均治疗2周。观察两组疗效、Hp根除率、胃肠激素和胃黏膜COX-2、NF-κB表达,观察两组治疗方案的药物安全性。结果:观察组的临床总有效率和Hp根除率均高于对照组(P<0.05)。观察组治疗2周后胃泌素(GAS)、胃动素(MTL)水平低于对照组,胃泌素-17(G-17)水平高于对照组(P<0.05)。观察组治疗后3个月的胃黏膜COX-2、NF-κB表达低于对照组(P<0.05)。两组不良反应发生率对比无差异(P>0.05)。结论:Hp阳性CAG患者采用四联疗法联合胃苏颗粒治疗,可有效控制患者胃肠激素水平,降低胃黏膜COX-2、NF-κB表达,疗效确切,且不良反应发生风险较低。
Objective:To observe the effect of Weisu granule combined with quadruple therapy on serum gastrointestinal hormone,gastric mucosal gastric mucosal oxidase-2(COX-2),nuclear transcription factor-κB(NF-κB)in patients with helicobacter pylori(Hp)positive chronic atrophic gastritis.Methods:120 patients with Hp positive CAG who were treated in Department of Gastroenterology,the second medical center,General Hospital of the Chinese people’s Liberation Army from July 2017 to June 2019were selected.According to the envelope lottery method,the patients were divided into observation group(60 cases,Weisu granule combined with quadruple therapy)and control group(60 cases,quadruple therapy),all patients were treated for 2 weeks.The curative effect,HP eradication rate,gastrointestinal hormone,gastric mucosa COX-2 and NF-κB of the two groups were observed.The drug safety of the two groups was observed.Results:The total clinical effective rate and Hp eradication rate of the observation group were higher than those of the control group(P<0.05).2 weeks after treatment,gastrin(GAS)and motilin(MTL)levels of the observation group were lower than those of the control group,and gastrin-17(G-17)level was higher than that of the control group(P<0.05).The expression of gastric mucosa COX-2 and NF-κB of the observation group at 3 months after treatment were significantly lower than those of the control group(P<0.05).There was no difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:HP positive CAG patients treated with quadruple therapy combined with Weisu granule can effectively control the level of gastrointestinal hormone and reduce gastric mucosa COX-2 and NF-κB expression,definite curative effect,and low risk of adverse reactions.
作者
王鸣
吴丽丽
周庆
吴诚
石卉
WANG Ming;WU Li-li;ZHOU Qing;WU Cheng;SHI Hui(Department of Gastroenterology,The Second Medical Center of the General Hospital of the Chinese People's Liberation Army,Beijing,100853,China)
出处
《现代生物医学进展》
CAS
2022年第10期1856-1859,1864,共5页
Progress in Modern Biomedicine
基金
北京市自然科学基金面上项目(7192197)。
