摘要
目的观察阿司匹林、胞磷胆碱联合蠲痹灸治疗对缺血性脑卒中(ICS)患者血流动力学与氧化应激相关指标的影响。方法选取2019年1—12月在中国人民解放军第九二三医院就诊的120例ICS患者作为研究对象,采用随机数字表法分为常规组与联合组。常规组采用阿司匹林与胞磷胆碱治疗,联合组在常规组治疗基础上联合蠲痹灸治疗。治疗周期均为8周,对比治疗前后2组患者的卒中严重程度(NIHSS)、日常生活能力(ADL)、大脑前动脉平均流速(Vmean)、血管搏动指数(PI)、血管阻力指数(RI)、超氧化物歧化酶(SOD)、内皮型一氧化氮合酶(eNOS)以及丙二醛(MDA)水平,并记录患者治疗期间不良反应发生情况。结果治疗结束后,联合组患者的NIHSS评分明显低于常规组(P<0.05),ADL评分明显高于常规组(P<0.05)。治疗结束后,2组患者的Vmean均上升,PI与RI均下降,其中联合组Vmean高于常规组,PI与RI均低于常规组,差异均有统计学意义(P均<0.05)。治疗结束后,2组患者的SOD、eNOS水平均上升,MDA水平均下降,其中联合组患者SOD、eNOS水平均明显高于常规组,MDA水平明显低于常规组,差异均有统计学意义(P均<0.05)。治疗期间,2组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论阿司匹林、胞磷胆碱联合蠲痹灸治疗ICS患者可明显减轻症状,提高生活能力,机制与改善血流动力学、减轻机体氧化应激反应有关。
Objective It is to observe the effect of aspirin,citicoline combined with Juanbi moxibustion on hemodynamics and oxidative stress-related indexes in patients with ischemic stroke(ICS).Methods A total of 120 ICS patients who were treated in the 923rd Hospital of the PLA from January 2019 to December 2019 were selected as the research subjects,and were divided into the conventional group and the combination group by random number table method.The conventional group was treated with aspirin and citicoline,and the combination group was treated with Chuanbi moxibustion on the basis of the conventional group.Both groups were treated for 8 weeks,the stroke severity(NIHSS),ability of daily living(ADL),anterior cerebral artery mean velocity(Vmean),vascular pulsatility index(PI),vascular resistance index(RI),the levels of superoxide dismutase(SOD),nitric oxide synthase(eNOS)and malondialdehyde(MDA)were compared between the two groups before and after treatment,and the occurrence of adverse reactions during treatment was recorded.Results At the end of treatment,the NIHSS score of the combination group was significantly lower than that of the conventional group(P<0.05),and the ADL score was significantly higher than that of the conventional group(P<0.05).After treatment,the Vmean of the patients in the two groups was increased,and the PI and RI were decreased,the Vmean of the combination group was higher and the PI and RI were lower than those of the conventional group,the differences were significant(all P<0.05).After treatment,the levels of SOD and eNOS of the patients in the two groups were increased,and the levels of MDA were decreased,the level of SOD and eNOS in the combination group were significantly higher and the level of MDA was significantly lower than those in the conventional group,the differences were all significant(all P<0.05).During the treatment,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Aspirin,citicoline combined with Juanbi moxibustion can significantly reduce symptoms and improve living ability in the treatment of ICS patients.The mechanism is related to improving hemodynamics and reducing oxidative stress.
作者
叶仿武
颜琼
吴理扬
沈维
YE Fangwu;YAN Qiong;WU Liyang;SHEN Wei(The 923rd Hospital of the PLA, Nanning 530021, Guangxi, China;The Fifth People's Hospital of Nanning, Nanning 530001, Guangxi, China)
出处
《现代中西医结合杂志》
CAS
2022年第12期1644-1648,共5页
Modern Journal of Integrated Traditional Chinese and Western Medicine
基金
广西壮族自治区卫生厅自筹经费科研课题项目(Z2014355)。
关键词
缺血性脑卒中
蠲痹灸
血流动力学
氧化应激
ischemic stroke
Chuanbi moxibustion
hemodynamics
oxidative stress
