摘要
运用网状Meta分析评价不同活血化瘀类口服中成药对子宫内膜异位症患者疗效的差异,为临床用药方案提供循证参考。计算机检索各大中、英文数据库,搜集活血化瘀类中成药联合常规治疗(试验组)vs常规治疗(对照组)子宫内膜异位症的随机对照试验(RCT)。筛选文献后,用Cochrane手册5.3推荐的偏倚风险评估工具评价纳入研究的质量。提取每个结局指标的结果数据,使用Stata 15.0软件进行网状Meta分析。共纳入44项RCTs, 4 345例患者,涉及9种中成药。网状Meta分析结果显示,(1)降低疼痛视觉模拟量表(VAS)评分方面,丹莪妇康煎膏+常规治疗>血府逐瘀胶囊+常规治疗>宫瘤消胶囊+常规治疗;(2)降低血清癌抗原CA125方面,小金胶囊+常规治疗>少腹逐瘀颗粒+常规治疗>丹莪妇康煎膏+常规治疗;(3)降低基础雌二醇(E_(2))方面,宫瘤消胶囊+常规治疗>小金胶囊+常规治疗>散结镇痛胶囊+常规治疗;(4)降低复发率方面,桂枝茯苓胶囊+常规治疗>血府逐瘀胶囊+常规治疗>丹莪妇康煎膏+常规治疗。综合比较,活血化瘀类口服中成药联合常规治疗在子宫内膜异位症的疗效方面优于单用常规治疗,但因纳入文献质量不高,故尚需开展大规模、高质量临床研究。
Network Meta-analysis was performed to systematically compare the efficacy of different Chinese patent medicines for activating blood and resolving stasis in the treatment of endometriosis and to provide evidence-based references for clinical medication regimens. The relevant randomized controlled trials(RCTs) involving Chinese patent medicines combined with conventional treatment(experimental group) vs conventional treatment(control group) were retrieved from Chinese and English literature databases. The bias risk assessment tool recommended in Cochrane handbook 5.3 was used to evaluate the quality of the included studies. The result data of each outcome index was extracted for network Meta-analysis in Stata 15.0. A total of 44 RCTs were included in this study, involving 4 345 patients and 9 Chinese patent medicines. The network Meta-analysis revealed the following trends.(1)In terms of reducing the visual analogue scale(VAS) scores, Dan′e Fukang Plaster+conventional treatment>Xuefu Zhuyu Capsules+conventional treatment>Gongliuxiao Capsules+conventional treatment.(2)In terms of reducing cancer antigen CA125, Xiaojin Capsules+conventional treatment>Shaofu Zhuyu Granules+conventional treatment>Dan′e Fukang Plaster+conventional treatment.(3)In terms of reducing estradiol(E_(2)), Gongliuxiao Capsules+conventional treatment>Xiaojin Capsules+conventional treatment>Sanjie Zhentong Capsules+conventional treatment.(4) In terms of reducing recurrence rate, Guizhi Fuling Capsules+conventional treatment>Xuefu Zhuyu Capsules+conventional treatment>Dan′e Fukang Plaster+conventional treatment. The peroral Chinese patent medicines for activating blood and resolving stasis combined with conventional treatment have better efficacy in the treatment of endometriosis than conventional treatment. However, considering the low quality of the included literature, large-scale high-quality clinical trials are needed in the future research.
作者
吴李征
柯妍
黄磊
林莉雯
黄英杰
裴芳利
曾诚
WU Li-zheng;KE Yan;HUANG Lei;LIN Li-wen;HUANG Ying-jie;PEI Fang-li;ZENG Cheng(Guangzhou University of Chinese Medicine,Guangzhou 510405,China;Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine,Shenzhen 518104,China;the First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2022年第11期3073-3087,共15页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(82074481)
邓高丕名中医传承工作室项目(粤中医办函[2019]5号)
罗颂平名中医传承工作室项目(粤中医办函[2019]5号)。
关键词
活血化瘀
中成药
子宫内膜异位症
网状Meta分析
activating blood and resolving stasis
Chinese patent medicine
endometriosis
network Meta-analysis
