摘要
目的分析老年首发精神分裂症患者头颅静息状态磁共振成像(MRI)特点。方法选取2019年5月至2020年5月本院收治的92例首发精神分裂症的老年患者作为观察组,并选取同期于本院进行体检的60例健康老年者作为对照组,均在静息状态下进行MRI扫描获取局部一致性(ReHo)和低频振幅(ALFF)值,并采用阳性与阴性症状量表(PANSS)评估临床症状,分析ReHo、ALFF与临床症状关系。结果与对照组比较,观察组ALFF值减低的脑区主要位于左侧中央后回、右侧中央后回、左侧颞中回、左侧楔前叶、右侧颞上回、右侧扣带中间、右侧颞中回、右侧枕下叶和左侧楔叶,ALFF值增高的脑区主要位于左侧眶额部(P<0.05);与对照组比较,观察组ReHo值减低的脑区主要位于左侧额中回、左侧颞上回和左侧中央前回,ReHo值增高的脑区主要位于右侧枕下回、尾状核、左侧中央前回、左侧额下回、右侧楔前叶和双侧额上回(P<0.05);Spearman相关分析显示,左侧颞中回和额中回与阳性症状评分呈负相关性,左侧和右侧颞上回与一般病理症状评分呈负相关性(P<0.05)。结论老年首发精神分裂症患者部分脑功能区活动异常,可能与临床症状相关。
Objective To analyze the brain resting-state magnetic resonance imaging(MRI)features of elderly patients with first-episode schizophrenia.Methods Ninety-two elderly patients with first-onset schizophrenia who were admitted and treated in the hospital between May 2019 and May 2020 were selected as the observation group.Meanwhile,60 healthy elderly people who received physical examination in the hospital during the same period were selected as the control group.All subjects completed MRI scan in resting state to obtain the regional homogeneity(ReHo)and amplitude of low frequency fluctuation(ALFF).The positive and negative symptom scale(PANSS)was used to evaluate clinical symptoms,and the relationship between ReHo,ALFF and clinical symptoms was analyzed.Results In the observation group,brain regions with reduced ALFF values mainly included the left posterior central gyrus,right posterior central gyrus,left middle temporal gyrus,left precuneus,right superior temporal gyrus,right middle cingulate,right middle temporal gyrus,right suboccipital lobe and left cuneus.Brain regions with increased ALFF values mainly included left orbital frontal area.Compared with the control group,there were statistically significant differences(P<0.05).In the observation group,brain regions with decreased ReHo values mainly included the left middle frontal gyrus,left superior temporal gyrus and left anterior central gyrus.The brain regions with increased ReHo values mainly included the right suboccipital gyrus,caudate nucleus,left anterior central gyrus,left inferior frontal gyrus,right precuneus and bilateral superior frontal gyrus.Compared with the control group,there were statistically significant differences(P<0.05).Spearman correlation analysis showed that the left middle temporal gyrus and frontal middle gyrus were negatively correlated with the positive symptom score.The left and right superior temporal gyri were negatively correlated with the general pathological symptom score(P<0.05).Conclusion In elderly patients with first-episode schizophrenia,some brain function areas are abnormal,which may be related to clinical symptoms.
作者
许珍
高成
邹峰
XU Zhen;GAO Cheng;ZOU Feng(Department of Psychiatry,Yingcheng Rongjun Hospital,Jinan 271199,Shandong Province,China;Department of Traditional Chinese Medicine,Jinan People's Hospital Affiliated to Shandong First Medical University,Jinan 271199,Shandong Province,China)
出处
《中国CT和MRI杂志》
2022年第8期31-34,共4页
Chinese Journal of CT and MRI
