摘要
目的:观察小柴胡汤加味联合恩替卡韦治疗慢性乙型肝炎(chroni chepatitis B,CHB)的临床疗效。方法:将280例CHB患者按照随机数字表法分为对照组和观察组,每组各140例。对照组给予恩替卡韦片治疗,观察组在对照组治疗的基础上给予小柴胡汤加味治疗。比较两组患者的临床疗效、不良反应发生率及治疗前后肝功能及肝纤维化相关指标变化情况。结果:观察组有效率为94.28%,对照组有效率为77.85%,两组患者有效率比较,差异具有统计学意义(P<005)。两组患者治疗后各项肝功能及肝纤维化相关指标低于本组治疗前,且治疗后观察组低于对照组,差异均有统计学意义(P<0.05)。观察组不良反应发生率为5.71%,对照组不良反应发生率为5.00%,两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:小柴胡汤加味联合恩替卡韦片治疗CHB,可改善患者肝功能,缓解肝纤维化程度。
Objective:To observe the clinical efficacy of Supplemented Minor Bupleurum Decoction combined with Entecavir Tab-lets on chronic hepatitis B(CHB).Methods:A total of 280 patients with CHB were randomly divided into the control group and the observation group,with 140 cases in each group.The control group was treated with Entecavir Tablets,while the observation group was treated with Supplemented Minor Bupleurum Decoction on the basis of the treatment of the control group.The clinical ef-ficacy,the incidence of adverse reactions and the changes of liver function and liver fibrosis related indicators before and after treatment were compared between the two groups.Results:The effective rate of the observation group was 94.28%and that of the control group was 77.85%.The difference between the two groups was statistically significant(P<0.05).After treatment,the liv-er function and liver fibrosis related indexes of the two groups were lower than those before treatment,and the above indexes of the observation group were lower than those of the control group,and all the differences were statistically significant(P<0.05).The incidence of adverse reactions was 5.71%in the observation group and 5.00%in the control group.There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Supplemented Minor Bupleurum Decoction combined with Entecavir Tablets in the treatment of CHB can improve the indexes of liver function,alleviate the degree of liver fibrosis,and has high safety.
作者
黄武明
谢林发
HUANG Wu-ming;XIE Lin-fa(Zixi People′s Hospital,Zixi,Jiangxi,China,335300)
出处
《河南中医》
2022年第9期1305-1308,共4页
Henan Traditional Chinese Medicine
基金
江西省自然科学基金项目(2012BAB216060)。
关键词
慢性乙型肝炎
小柴胡汤加味
恩替卡韦片
中西医结合疗法
《伤寒论》
张仲景
chronic hepatitis B(CHB)
Supplemented Minor Bupleurum Decoction
Entecavir Tablets
integrated traditional Chi-nese and Western medicine
Treatise on Cold Damage Diseases
Zhang Zhong-jing
