摘要
目的:观察清热逐瘀汤对ⅢB型慢性前列腺炎伴勃起功能障碍患者阴茎血流动力学及单核细胞趋化因子-1(MCP-1)的影响。方法:采用信封法将107例ⅢB型慢性前列腺炎伴勃起功能障碍患者分为2组,对照组53例给予伐地那非治疗,观察组54例在对照组基础上联合清热逐瘀汤治疗。比较2组临床疗效及治疗前后前列腺液转化生长因子-β1(TGF-β1)、单核细胞趋化因子-1(MCP-1)、血小板衍生生长因子-BB(PDGF-BB)水平、阴茎血流动力学指标、尿动力学指标。结果:与同组治疗前比较,治疗后2组TGF-β1、MCP-1、PDGF-BB、收缩期峰值流速(PSV)、最大尿道闭合压(MUCP)及前列腺症状评分均下降(P<0.05),舒张末期流速(EDV)、阻力指数(RI)、平均尿流率(AFR)、最大尿流率变化(MFR)水平及国际勃起功能指数评分均上升(P<0.05);与对照组治疗后比较,观察组治疗后MCP-1、PDGF-BB、TGF-β1、PSV、MUCP水平及前列腺症状评分均较低(P<0.05),AFR、MFR、EDV、RI水平及国际勃起功能指数评分均较高(P<0.05)。观察组总有效率92.59%,高于对照组75.47%(P<0.05)。结论:伐地那非联合清热逐瘀汤可通过降低前列腺因子水平,改善勃起功能,有效治疗ⅢB型慢性前列腺炎伴勃起功能障碍患者。
Objective:To observe the effects of Qingre Zhuyu tang on penile hemodynamics and monocyte chemoattractant protein-1(MCP-1)in patients with typeⅢB chronic prostatitis complicated with erectile dysfunction.Methods:A total of 107 cases of patients with typeⅢB chronic prostatitis complicated with erectile dysfunction were divided into the control group and the observation group according to the sealed envelope method,with 53 and 54 cases in each group respectively.The control group was treated with vardenafil,and the observation group was additionally treated with Qingre Zhuyu tang based on the treatment of the control group.The levels of prostatic transforming growth factor-β1(TGF-β1),monocyte chemoattractant protein-1(MCP-1),platelet-derived growth factor-BB(PDGF-BB)and the indexes of penile hemodynamics and urodynamics before and after treatment as well as the clinical effects in the two groups were compared.Results:When compared with those before treatment,TGF-β1,MCP-1,PDGF-BB,peak systolic velocity(PSV),maximum urethral closure pressure(MUCP)and prostate symptom scores after treatment in the two groups were decreased(P<0.05),and the levels of end diastolic velocity(EDV),resistance index(RI),average urinary flow rate(AFR),changes in maximum urinary flow rate(MFR)and international evectile function index scores were increased(P<0.05).After treatment,the levels of MCP-1,PDGF-BB,TGF-β1,PSV,MUCP and prostate symptom scores in the observation group were lower than those in the control group(P<0.05),and the levels of AFR,MFR,EDV,RI and international erectile function index scores were higher(P<0.05).The total effective rate was 92.59%in the observation group,higher than that of 75.47%in the control group(P<0.05).Conclusion:Vardenafil combined with Qingre Zhuyu tang can effectively treat patients with typeⅢB chronic prostatitis complicated with erectile dysfunction by reducing the levels of prostatic factors and improving erectile function.
作者
谭成
何丹
叶云
李涛
TAN Cheng;HE Dan;YE Yun;LI Tao
出处
《新中医》
CAS
2022年第13期73-77,共5页
New Chinese Medicine
基金
宁波市科技计划项目(2019B10035)。
